{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:38:22Z","timestamp":1787924302201,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We summarize herein our 14\u2010year experience of conventional treatment outcomes before the era of molecular\u2010targeted therapy and immunotherapy. Specifically, we conducted a retrospective review of our 252 patients with primary cutaneous melanoma (acral lentiginous melanoma [<jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content>], <jats:italic>n<\/jats:italic>\u00a0=\u00a0121; non\u2010acral lentiginous melanoma [non\u2010<jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content>], <jats:italic>n<\/jats:italic>\u00a0=\u00a0131), and compared the prognostic factors between <jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content>. Melanoma\u2010specific survival and disease\u2010free survival were estimated using the Kaplan\u2013Meier method. Regarding the results, all patients were Japanese (106 male and 146 female), with a mean age of 60.1\u00a0years. Among <jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content> patients, age was elder and primary tumor size was larger than non\u2010<jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content>. As for tumor thickness, <jats:italic>in\u00a0situ<\/jats:italic> lesions were more frequently observed in <jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content>. There was no significant difference in the distribution of tumor thickness between the two groups when excluding the <jats:italic>in\u00a0situ<\/jats:italic> lesions. For treatment of the primary melanoma, 248 patients (98.4%) had undergone curative surgical excision and 120 patients with more than 1\u00a0mm or ulcerated melanoma had undergone sentinel lymph node biopsy. Patients with systemic metastasis primarily underwent dacarbazine\u2010based chemotherapy. The Kaplan\u2013Meier survival curves revealed no significant difference in melanoma\u2010specific survival and disease\u2010free survival between those with <jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content>. The results also showed that both <jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content>, when they initially metastasize, first affect the regional lymph nodes. Incisional biopsy was not an adverse prognostic factor. These results suggest that <jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content> does not differ in its biological behavior from non\u2010<jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content>, so we can consider <jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content> as being equivalent to non\u2010<jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content>. The initial treatment for <jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content> and non\u2010<jats:styled-content style=\"fixed-case\">ALM<\/jats:styled-content> can involve the same strategy.<\/jats:p>","DOI":"10.1111\/1346-8138.13834","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T09:26:51Z","timestamp":1490434011000},"page":"932-938","source":"Crossref","is-referenced-by-count":46,"title":["Acral lentiginous melanoma versus other melanoma: A single\u2010center analysis in Japan"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7617-7038","authenticated-orcid":false,"given":"Maiko","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaku","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Research and Clinical Center for Yusho and Dioxin Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Division of Skin Surface Sensing Department of Dermatology Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Hagihara","sequence":"additional","affiliation":[{"name":"Department of Health Services Management and Policy Graduate School of Medical Sciences 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