{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:33:27Z","timestamp":1771457607333,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stress\u2010induced scratching is an issue in patients with adult atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>). Although itching and stress are believed to be intimately related, no objective index is available; therefore, most evaluations are subjective. Using saliva, which is easily collected, we investigated the degree to which <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> severity and patient stress levels are reflected in stress proteins in the saliva. Here, we evaluated the severity (Scoring Atopic Dermatitis [<jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content>] score), stress (State\u2013Trait Anxiety Index [<jats:styled-content style=\"fixed-case\">STAI<\/jats:styled-content>] score), personality (Tokyo University Egogram [<jats:styled-content style=\"fixed-case\">TEG<\/jats:styled-content>] <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> score) and quality of life (Dermatology Life Quality Index [<jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>] score) of 51 patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> who were examined in the Department of Dermatology of Shimane University between April and December 2015. We collected saliva and measured salivary chromogranin A (CgA), amylase and cortisol. The amount of salivary CgA per protein in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was correlated with their <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content> score (<jats:italic>r<\/jats:italic> = 0.458, <jats:italic>P<\/jats:italic> &lt; 0.001). There was no correlation between cortisol or amylase levels and <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content> score. <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content> score was correlated with <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = 0.390, <jats:italic>P<\/jats:italic> = 0.006). CgA per protein was correlated with <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = 0.393, <jats:italic>P<\/jats:italic> = 0.004). There was no correlation between scores for the anxiety component of the <jats:styled-content style=\"fixed-case\">STAI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TEG II<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>. Our results suggested that patients with more severe <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> may have high stress levels. The personalities of these patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> tended to involve elevated anxiety levels.<\/jats:p>","DOI":"10.1111\/1346-8138.13852","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T15:55:19Z","timestamp":1492098919000},"page":"920-926","source":"Crossref","is-referenced-by-count":7,"title":["Salivary chromogranin A levels correlate with disease severity but do not reflect anxiety or personality of adult patients with atopic dermatitis"],"prefix":"10.1111","volume":"44","author":[{"given":"Sakae","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Dermatology Shimane University Faculty of Medicine Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shimane University Faculty of Medicine Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeyasu","family":"Kakamu","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Preventive Medicine Fukushima Medical University School of Medicine Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Minami\u2010Hori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eishin","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shimane University Faculty of Medicine Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00706.x"},{"key":"e_1_2_7_3_1","first-page":"78","article-title":"Stress and the 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