{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:53:56Z","timestamp":1791284036714,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T00:00:00Z","timestamp":1492041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>\n \n Metastatic extramammary Paget's disease (\n EMPD<\/jats:styled-content>\n ) is a rare cancer with no standardized treatment. We report two cases of metastatic\n EMPD<\/jats:styled-content>\n treated with a modified weekly\n PET<\/jats:styled-content>\n (cisplatin, epirubicin and paclitaxel) regimen given biweekly (i.e. 2 weeks on\/2 weeks off) that had durable responses. Case 1 was a 74\u2010year\u2010old man with\n EMPD<\/jats:styled-content>\n metastatic to lymph nodes, lung, and bone who presented with a hemorrhagic tumor on the scrotum. We tried the\n PET<\/jats:styled-content>\n regimen weekly, but adjusted the interval to biweekly after two doses because of hematological side\u2010effects. After five doses, he showed a partial response (\n PR<\/jats:styled-content>\n ) on imaging, including the bone lesions. The lesions have remained the same size for 1 year. Case 2 was a 65\u2010year\u2010old man with\n EMPD<\/jats:styled-content>\n metastatic to a right inguinal lymph node who presented with an erosive tumor on the scrotum. He was started on weekly docetaxel. However, the lymph node grew and iliac lymph node metastasis developed. Therefore, we tried the\n PET<\/jats:styled-content>\n regimen with a 2 weeks on\/2 weeks off schedule. After five doses, he showed a\n PR<\/jats:styled-content>\n . In both cases, all adverse effects were manageable and this modified regimen could be administrated on an outpatient basis. With no current validated chemotherapy regimen, clinicians may consider a modified weekly\n PET<\/jats:styled-content>\n regimen in future treatment of metastatic\n EMPD<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/1346-8138.13869","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T11:56:13Z","timestamp":1492084573000},"page":"1148-1151","source":"Crossref","is-referenced-by-count":12,"title":["Modified weekly regimen of cisplatin, epirubicin and paclitaxel induced a durable response in two cases of metastatic extramammary Paget's disease"],"prefix":"10.1111","volume":"44","author":[{"given":"Ikuko","family":"Hirai","sequence":"first","affiliation":[{"name":"Department of Dermatology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-4590","authenticated-orcid":false,"given":"Takeru","family":"Funakoshi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Keio University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30093.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12788"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01149.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13200"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006429205363"},{"key":"e_1_2_5_7_1","first-page":"1787","article-title":"A case of genital Paget's carcinoma with multiple bone metastases that responded to weekly PET (cisplatin\u2010epirubicin\u2010paclitaxel) therapy","volume":"114","author":"Fukuyama K","year":"2004","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.5227\/skincancer.24.99"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.13869","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:24:34Z","timestamp":1791282274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,13]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/1346-8138.13869"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13869","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,13]]}}}