{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:54:14Z","timestamp":1791284054629,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T00:00:00Z","timestamp":1497571200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Autoimmune autonomic ganglionopathy (\n                    <jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content>\n                    ), clinically characterized by gastrointestinal dysmotility, orthostatic hypotension and tonic pupils, is an idiopathic acquired disorder of the autonomic nervous system elicited by antibodies against ganglionic acetylcholine receptor (\n                    <jats:styled-content style=\"fixed-case\">gAChR<\/jats:styled-content>\n                    ). We encountered a 60\u2010year\u2010old man who presented with severe anhidrosis, difficulty in thermoregulation, orthostatic hypotension, gastrointestinal dysmotility, tonic pupils and ptosis. Histologically, an anhidrotic skin sample was normal. Routine laboratory examinations of blood, urine and cerebrospinal fluid returned no abnormal findings. Serological examination revealed antibodies against \u03b13 and \u03b24 subunits of\n                    <jats:styled-content style=\"fixed-case\">gAChR<\/jats:styled-content>\n                    . The diagnosis was\n                    <jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content>\n                    . As sudomotor dysfunction reflects ganglionic neuropathy in\n                    <jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content>\n                    , we concluded that his anhidrosis was attributable to\n                    <jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content>\n                    . Anhidrosis is an important clue for the diagnosis of\n                    <jats:styled-content style=\"fixed-case\">AAG<\/jats:styled-content>\n                    , a rare neurological disorder.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.13870","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T01:06:44Z","timestamp":1497575204000},"page":"1160-1163","source":"Crossref","is-referenced-by-count":9,"title":["Case of autoimmune autonomic ganglionopathy manifesting anhidrosis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-1416","authenticated-orcid":false,"given":"Asuka","family":"Yoshifuku","sequence":"first","affiliation":[{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Department of Neurology and Geriatrics Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sakiyama","sequence":"additional","affiliation":[{"name":"Department of Neurology and Geriatrics Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Nagasaki Kawatana Medical Center Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Nakane","sequence":"additional","affiliation":[{"name":"Department of Neurology (Molecular Neurology and Therapeutics) Kumamoto University Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Kanekura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000212370"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10556"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53491-0.00025-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0118312"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1806"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009213431204"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2008.12.002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32833d4c7f"},{"key":"e_1_2_6_10_1","first-page":"20","article-title":"Rheumatic diseases 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