{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:53:56Z","timestamp":1791284036257,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T00:00:00Z","timestamp":1492819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T00:00:00Z","timestamp":1492819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ficolins, a group of oligomeric lectins consisting of three isoforms (H\u2010, L\u2010 and M\u2010ficolin), contribute to innate immunity via activating the complement pathway and\/or acting directly as opsonins against pathogens and apoptotic cells. Because apoptotic cells likely drive the development of systemic sclerosis (\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c) partly through innate immunity, we assessed the clinical association of serum H\u2010ficolin levels in\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c patients. Despite no difference in serum H\u2010ficolin levels between\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c and control subjects,\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c patients with decreased serum H\u2010ficolin levels tended to have a higher prevalence of interstitial lung disease (\n                    <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>\n                    ). More importantly, serum H\u2010ficolin levels inversely correlated with ground\u2010glass opacity score on chest computed tomography in\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c\u2010\n                    <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>\n                    patients. Therefore, H\u2010ficolin\u2010related innate immunity may be involved in\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c\u2010\n                    <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>\n                    development.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.13877","type":"journal-article","created":{"date-parts":[[2017,4,22]],"date-time":"2017-04-22T03:22:54Z","timestamp":1492831374000},"page":"1168-1171","source":"Crossref","is-referenced-by-count":9,"title":["Serum H\u2010ficolin levels: Clinical association with interstitial lung disease in patients with systemic sclerosis"],"prefix":"10.1111","volume":"44","author":[{"given":"Takuya","family":"Miyagawa","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo 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