{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T09:14:23Z","timestamp":1777022063982,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rosacea is a chronic dermatological disease. <jats:italic>Helicobacter pylori<\/jats:italic> has been discussed as one of its causative factors. In this clinical trial study, we attempted to evaluate the effect of <jats:italic>H. pylori<\/jats:italic> standard eradication protocol on the rosacea clinical course. In this single\u2010arm clinical trial, patients ascertained to have <jats:italic>H. pylori<\/jats:italic> infection based on serological studies were assessed to examine existence of rosacea. Patients with concurrent rosacea and <jats:italic>H. pylori<\/jats:italic> infection were included in the study and underwent standard <jats:italic>H. pylori<\/jats:italic> eradication therapy. Rosacea was evaluated using the Duluth rosacea grading score at the beginning, 2 months later and at the end of the trial (day 180). Of 872 patients positive for <jats:italic>H. pylori<\/jats:italic>, 167 patients (19.15%) manifested the clinical features of rosacea. The patients with concurrent rosacea were younger (<jats:italic>P<\/jats:italic> &lt; 0.001) and with a female sex predominance (<jats:italic>P<\/jats:italic> = 0.03) when compared with rosacea\u2010free patients. Of 167 patients, 150 received <jats:italic>H. pylori<\/jats:italic> eradication therapy, demonstrating a 92% (138\/150) cure rate. The rosacea Duluth score grading on day 0, 60 and 180 among 138 patients significantly decreased in most of the criteria except for telangiectasias (<jats:italic>P<\/jats:italic> = 0.712), phymatous changes (<jats:italic>P<\/jats:italic> = 0.535) and the existence of peripheral involvement (<jats:italic>P<\/jats:italic> = 0.431). The present study concluded that <jats:italic>H. pylori<\/jats:italic> eradication leads to improvement of rosacea.<\/jats:p>","DOI":"10.1111\/1346-8138.13878","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T08:13:54Z","timestamp":1493367234000},"page":"1033-1037","source":"Crossref","is-referenced-by-count":22,"title":["Effects of <i>Helicobacter pylori<\/i> treatment on rosacea: A single\u2010arm clinical trial study"],"prefix":"10.1111","volume":"44","author":[{"given":"Parviz","family":"Saleh","sequence":"first","affiliation":[{"name":"Chronic Kidney Diseases Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Naghavi\u2010Behzad","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Committee Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamdieh","family":"Herizchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Mirza\u2010Aghazadeh\u2010Attari","sequence":"additional","affiliation":[{"name":"Students\u2019 Research Committee Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6379-3373","authenticated-orcid":false,"given":"Reza","family":"Piri","sequence":"additional","affiliation":[{"name":"Medical Philosophy and History Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Acne and Rosacea","author":"Plewig G","year":"2012"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp042829"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12385"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.043"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","unstructured":"SteinhoffM BuddenkotteJ AubertJet al.Clinical cellular and molecular aspects in the pathophysiology of rosacea. 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