{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:54:10Z","timestamp":1791284050732,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T00:00:00Z","timestamp":1494633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T00:00:00Z","timestamp":1494633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>\n \n Vitiligo is an acquired skin disease with pigmentary disorder. Autoimmune destruction of melanocytes is thought to be major factor in the etiology of vitiligo. mi\n RNA<\/jats:styled-content>\n \u2010based regulators of gene expression have been reported to play crucial roles in autoimmune disease. Therefore, we attempt to profile the mi\n RNA<\/jats:styled-content>\n expressions and predict their potential targets, assessing the biological functions of differentially expressed mi\n RNA<\/jats:styled-content>\n . Total\n RNA<\/jats:styled-content>\n was extracted from peripheral blood of vitiligo (experimental group,\n n<\/jats:italic>\n = 5) and non\u2010vitiligo (control group,\n n<\/jats:italic>\n = 5) age\u2010matched patients. Samples were hybridized to a mi\n RNA<\/jats:styled-content>\n array. Box, scatter and principal component analysis plots were performed, followed by unsupervised hierarchical clustering analysis to classify the samples. Quantitative reverse transcription polymerase chain reaction (\n RT<\/jats:styled-content>\n \u2013\n PCR<\/jats:styled-content>\n ) was conducted for validation of microarray data. Three different databases, TargetScan,\n PITA<\/jats:styled-content>\n and micro\n RNA<\/jats:styled-content>\n .org, were used to predict the potential target genes. Gene ontology (\n GO<\/jats:styled-content>\n ) annotation and pathway analysis were performed to assess the potential functions of predicted genes of identified mi\n RNA<\/jats:styled-content>\n . A total of 100 (29 upregulated and 71 downregulated) mi\n RNA<\/jats:styled-content>\n were filtered by volcano plot analysis. Four mi\n RNA<\/jats:styled-content>\n were validated by quantitative\n RT<\/jats:styled-content>\n \u2013\n PCR<\/jats:styled-content>\n as significantly downregulated in the vitiligo group. The functions of predicted target genes associated with differentially expressed mi\n RNA<\/jats:styled-content>\n were assessed by\n GO<\/jats:styled-content>\n analysis, showing that the\n GO<\/jats:styled-content>\n term with most significantly enriched target genes was axon guidance, and that the axon guidance pathway was most significantly correlated with these mi\n RNA<\/jats:styled-content>\n . In conclusion, we identified four downregulated mi\n RNA<\/jats:styled-content>\n in vitiligo and assessed the potential functions of target genes related to these differentially expressed mi\n RNA<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/1346-8138.13886","type":"journal-article","created":{"date-parts":[[2017,5,13]],"date-time":"2017-05-13T02:10:13Z","timestamp":1494641413000},"page":"1138-1144","source":"Crossref","is-referenced-by-count":24,"title":["Altered expression of four mi\n RNA<\/scp>\n (miR\u20101238\u20103p, miR\u2010202\u20103p, miR\u2010630 and miR\u2010766\u20103p) and their potential targets in peripheral blood from vitiligo patients"],"prefix":"10.1111","volume":"44","author":[{"given":"Zhiwei","family":"Shang","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital, and College of Clinical Medicine of Zhengzhou University Zhengzhou China"},{"name":"Department of Dermatology The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-6500","authenticated-orcid":false,"given":"Hongwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital, and College of Clinical Medicine of Zhengzhou University Zhengzhou 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