{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:53:56Z","timestamp":1791284036689,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>\n \n A 67\u2010year\u2010old woman exhibited chilblain\u2010like erythema on the bilateral auricles, erythema with hyperkeratosis on the sides of fingers and the bilateral elbows, and erythema on the extensor\/flexor sides of the finger joints and the iliac regions. Fine crackles were audible on the dorsal side of the bilateral lower lung regions. We diagnosed clinically amyopathic dermatomyositis accompanied by rapidly progressive interstitial pneumonia. While we initiated immunosuppressive therapy, the respiratory failure showed no responses. We performed endotoxin adsorption therapy using polymyxin B\u2010immobilized fiber column direct hemoperfusion (\n PMX<\/jats:styled-content>\n \u2010\n DHP<\/jats:styled-content>\n ). After the first\n PMX<\/jats:styled-content>\n \u2010\n DHP<\/jats:styled-content>\n session, the respiratory condition was slightly improved but it soon deteriorated. At the second\n PMX<\/jats:styled-content>\n \u2010\n DHP<\/jats:styled-content>\n session, subcutaneous and mediastinal emphysema was noted. The patient died, showing no improvement in the respiratory condition. We measured the levels of serum interleukin (\n IL<\/jats:styled-content>\n )\u20106, tumor necrosis factor (\n TNF<\/jats:styled-content>\n )\u2010\u03b1 and\n IL<\/jats:styled-content>\n \u201010 before and after\n PMX<\/jats:styled-content>\n \u2010\n DHP<\/jats:styled-content>\n and compared them with previously reported levels. The levels of\n TNF<\/jats:styled-content>\n \u2010\u03b1 and\n IL<\/jats:styled-content>\n \u201010 showed no or slight changes, but those of\n IL<\/jats:styled-content>\n \u20106 at the beginning of the treatment were higher compared with previous reports. After the first\n PMX<\/jats:styled-content>\n \u2010\n DHP<\/jats:styled-content>\n , the\n IL<\/jats:styled-content>\n \u20106 level decreased with slight improvement in respiratory condition. However, after the second\n PMX<\/jats:styled-content>\n \u2010\n DHP<\/jats:styled-content>\n , it increased markedly with exacerbation of the respiratory failure. The serum\n IL<\/jats:styled-content>\n \u20106 level is considered to be effective for the evaluation of the disease activity and prognosis under the treatment by\n PMX<\/jats:styled-content>\n \u2010\n DHP<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/1346-8138.13887","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T20:53:52Z","timestamp":1495572832000},"page":"1164-1167","source":"Crossref","is-referenced-by-count":14,"title":["Clinically amyopathic dermatomyositis with rapidly progressive interstitial pneumonia: The relation between the disease activity and the serum interleukin\u20106 level"],"prefix":"10.1111","volume":"44","author":[{"given":"Hazuki","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Dermatology Wakayama Medical University Graduate School of Medicine Wakayama Japan"},{"name":"Department of Dermatology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-9262","authenticated-orcid":false,"given":"Takaharu","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University Graduate School of Medicine Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukumi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University Graduate School of Medicine Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120621"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep375"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0246-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.1998.06086.x"},{"key":"e_1_2_5_6_1","first-page":"423","article-title":"Endotoxin shock due to Vibrio vulnificus infection","volume":"16","author":"Ikeda T","year":"2006","journal-title":"Br J Dermatol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.6018"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.10019"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.47.0639"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.852847"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/750275"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2013.844390"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu258"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/815245"},{"key":"e_1_2_5_15_1","first-page":"9","article-title":"Recent treatment of interstitial lung disease with idiopathic inflammatory myositis","volume":"9","author":"Kawasumi H","year":"2015","journal-title":"Clin Med Insights. 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