{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:54:14Z","timestamp":1791284054538,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H06280"],"award-info":[{"award-number":["15H06280"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Adult\u2010onset Still's disease (\n                    <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>\n                    ) is characterized by multiple systemic inflammation of unknown etiology. Although the typical eruption of\n                    <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>\n                    is salmon\u2010pink rheumatoid rash on the trunk and extremities, persistent pruritic papules and plaques have also been reported. Correlations between serum cytokines, including interleukin\u20106 and \u201018, and disease activity in\n                    <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>\n                    have been reported. Activated signal transducer and activator of transcription 3 (\n                    <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                    3) is transported into the nucleus, where it functions as a transcription factor that regulates genes involved in cell survival and inflammation. To assess whether\n                    <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                    3 was phosphorylated in skin samples from\n                    <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>\n                    patients, we conducted immunohistochemical analysis of affected and unaffected lesions from four\n                    <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>\n                    patients in comparison with 10 normal controls. Quantitative analysis was conducted by measuring the ratio of epidermal keratinocytes with phosphorylated\n                    <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                    3 (p\u2010\n                    <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                    3)\u2010positive nuclei to total epidermal keratinocytes. p\u2010\n                    <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                    3 was found to be more strongly expressed in the nuclei in the epidermis of\n                    <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>\n                    than in normal controls. Quantification of the data revealed significant differences in staining for p\u2010\n                    <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                    3 between\n                    <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>\n                    and normal skin. Our findings suggest that phosphorylation of\n                    <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>\n                    3 may be a potential therapeutic target for\n                    <jats:styled-content style=\"fixed-case\">AOSD<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.13888","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T01:18:46Z","timestamp":1493860726000},"page":"1172-1175","source":"Crossref","is-referenced-by-count":6,"title":["Phosphorylated signal transducer and activator of transcription 3 in the epidermis in adult\u2010onset Still's disease"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5958-2875","authenticated-orcid":false,"given":"Takuya","family":"Takeichi","sequence":"first","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Muro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiho","family":"Teshigawara","sequence":"additional","affiliation":[{"name":"Department of General Medicine\/Family and Community Medicine Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of General Medicine\/Family and Community Medicine Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaro","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of General Medicine\/Family and Community Medicine Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247150"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12426"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.04.063"},{"issue":"2","key":"e_1_2_6_5_1","first-page":"396","article-title":"Elevated serum interleukin 6, interferon\u2010gamma, and 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