{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:53:56Z","timestamp":1791284036956,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Xeroderma pigmentosum (\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    ) is a genetic photosensitive disorder in which patients are highly susceptibe to skin cancers on the sun\u2010exposed body sites. In Japan, more than half of patients (30% worldwide) with\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    show complications of idiopathic progressive, intractable neurological symptoms with poor prognoses. Therefore, this disease does not merely present with dermatological symptoms, such as photosensitivity, pigmentary change and skin cancers, but is \u201can intractable neurological and dermatological disease\u201d. For this reason, in March 2007, the Japanese Ministry of Health, Labor and Welfare added\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    to the neurocutaneous syndromes that are subject to government research initiatives for overcoming intractable diseases.\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    is one of the extremely serious photosensitive disorders in which patients easily develop multiple skin cancers if they are not completely protected from ultraviolet radiation.\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    patients thus need to be strictly shielded from sunlight throughout their lives, and they often experience idiopathic neurodegenerative complications that markedly reduce the quality of life for both the patients and their families. Hospitals in Japan often see cases of\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    as severely photosensitive in children, and as advanced pigmentary disorders of the sun\u2010exposed area with multiple skin cancers in adults (aged in their 20\u201340s), making\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    an important disease to differentiate in everyday clinical practice. It was thus decided that there was a strong need for clinical practice guidelines dedicated to\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    . This process led to the creation of new clinical practice guidelines for\n                    <jats:styled-content style=\"fixed-case\">XP<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.13907","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T15:38:45Z","timestamp":1501774725000},"page":"1087-1096","source":"Crossref","is-referenced-by-count":67,"title":["Xeroderma pigmentosum clinical practice guidelines"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0803-9455","authenticated-orcid":false,"given":"Shinichi","family":"Moriwaki","sequence":"first","affiliation":[{"name":"Department of Dermatology Osaka Medical College  Takatsuki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Neurology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Brain Development and Neural Regeneration Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitada","family":"Sakai","sequence":"additional","affiliation":[{"name":"Division of Rehabilitation Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6784-2849","authenticated-orcid":false,"given":"Chikako","family":"Nishigori","sequence":"additional","affiliation":[{"name":"Division of Dermatology Kobe University Graduate School of Medicine (Chairperson at Xeroderma pigmentosum clinical practice guidelines revision committee)  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Xeroderma pigmentosum clinical practice guidelines revision committee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"252","article-title":"On diseases of the skin, including the exanthemata","volume":"61","author":"Hebra F","year":"1874","journal-title":"New Synposium Soc"},{"key":"e_1_2_14_3_1","first-page":"29","article-title":"Xeroderma pigmentosum","volume":"4","author":"Kaposi M","year":"1883","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/218652a0"},{"key":"e_1_2_14_5_1","unstructured":"NishigoriC.1. Analysis of the patient survey for development of clinical practice guidelines for xeroderma pigmentosum. [in Japanese] 2. An association between the abnormalities in migration in the cells in Group A of xeroderma pigmentosum and the onset of neurological symptoms; a research study on neurocutaneous syndrome. [in Japanese] Grant\u2010in\u2010Aid by the Ministry of Health Labour and Welfare (government research initiatives for overcoming intractable diseases) 2011 Summary and allotment working papers 2012 119\u2013123."},{"key":"e_1_2_14_6_1","first-page":"561","article-title":"Committee to develop guidelines for gene diagnosis in skin disease Guidelines for gene diagnosis in skin disease (the first edition) [in Japanese]","volume":"122","author":"Sawamura D.","year":"2012","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690020057009"},{"key":"e_1_2_14_8_1","first-page":"2488","article-title":"Neurological symptoms of Group A of xeroderma pigmentosum and molecular genetic study","volume":"51","author":"Mimaki T","year":"1993","journal-title":"Jpn J Clin Med"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2006.06.010"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.14"},{"key":"e_1_2_14_11_1","first-page":"301","volume-title":"A Series of Latest Dermatology [in Japanese]","author":"Nishigori C","year":"2003"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12038"},{"key":"e_1_2_14_13_1","first-page":"58","article-title":"Treatment, rehabilitation, and home care of xeroderma pigmentosum (XP); 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