{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:26:44Z","timestamp":1791293204549,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T00:00:00Z","timestamp":1495065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of bilateral annular breast keloids in a 72\u2010year\u2010old woman who had been suffering from bilateral breast cancers. Histopathologically, the keloids showed unique distribution of \u03b1\u2010SMA+, CD34\u2212 myofibroblasts and \u03b1\u2010SMA\u2212, CD34+ fibroblasts depending on the region. High serum levels of tumor growth factor\u2010\u03b2 were detected at 6 months after the development of the breast keloids, but not at 10 months. CD163\u2010positive cells were abundantly detected in the skin of the elevated portion of the keloids. In contrast, these cells were considerably less numerous in the skin of the central healing portion compared with the skin of the elevated expanding portion. One interesting idea based on these results is that high levels of tumor growth factor\u2010\u03b2 released from CD163\u2010positive cells played a crucial role in the formation of breast keloids through active induction of fibroblast differentiation into myofibroblasts. The present case strongly supports the previously proposed idea that keloids can form as a paraneoplastic phenomenon in breast cancer patients with keloid constitution.<\/jats:p>","DOI":"10.1111\/1346-8138.13910","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T11:56:10Z","timestamp":1495108570000},"page":"1303-1308","source":"Crossref","is-referenced-by-count":6,"title":["Bilateral breast keloids in an elderly woman associated with bilateral breast cancers and high concentration of serum tumor growth factor\u2010\u03b2"],"prefix":"10.1111","volume":"44","author":[{"given":"Masanobu","family":"Sakaguchi","sequence":"first","affiliation":[{"name":"Division of Dermatology Tohoku Medical and Pharmaceutical University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Internal Related Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiyoshi","family":"Fujishima","sequence":"additional","affiliation":[{"name":"Department of Pathology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Surgery Tohoku Medical and Pharmaceutical University Wakabayashi Hospital Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kozaru","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nishiwaki Municipal Hospital Nishiwaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ban","sequence":"additional","affiliation":[{"name":"Ban Dermato Plastic Clinic Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6792-5708","authenticated-orcid":false,"given":"Masahiro","family":"Oka","sequence":"additional","affiliation":[{"name":"Division of Dermatology Tohoku Medical and Pharmaceutical University Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70048-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000164538.72375.93"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.110701"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089169708300517"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.4.271"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2011.00708.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.246"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.041802ad"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35043051"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400605"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb01098.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1089"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/948098"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.4236\/abb.2013.410A4003"},{"key":"e_1_2_5_16_1","first-page":"4413","article-title":"Prognostic significance of TGF beta 1 and TGF beta 3 in human breast carcinoma","volume":"20","author":"Ghellal A","year":"2000","journal-title":"Anticancer Res"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13910","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:11:43Z","timestamp":1695535903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,18]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/1346-8138.13910"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13910","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,18]]}}}