{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:51:09Z","timestamp":1787500269959,"version":"build-2736575974"},"reference-count":134,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Alopecia areata is a chronic, recurrent and non\u2010scarring alopecia. The prognoses of patients are very diverse. The larger the area of hair loss, the poorer the treatment response and greater the probability of chronic disease progression. Numerous treatments have been introduced, but curative treatments have yet to be established. The long\u2010term efficacy of the current treatments is minimal, and the therapeutic response varies widely. Recent clinical trials have attempted to apply therapeutic metrics, such as the Severity of Alopecia Tool, and many have been designed as randomized controlled studies, enabling a more precise evaluation of existing treatments. There have been updates in practice, efficacy or indications of therapeutics that have been previously used. Moreover, the use of novel treatments such as biologics has recently been introduced. Commonly, the most important factor in determining the treatment modality for alopecia areata has been the extent of hair loss. However, if the disease activity is high and likely to progress, combination therapy with adjuvant modalities will be more desirable. This review will discuss the therapeutic effects of existing and newly\u2010introduced treatments based on their quantity, quality of evidence and expected complications. In addition, an algorithmic approach to management of alopecia areata is proposed according to clinical subtype, severity, onset and activity of the disease.<\/jats:p>","DOI":"10.1111\/1346-8138.13933","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T02:03:07Z","timestamp":1498010587000},"page":"1199-1211","source":"Crossref","is-referenced-by-count":50,"title":["Management of alopecia areata: Updates and algorithmic approach"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-9449","authenticated-orcid":false,"given":"Solam","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology Institute of Hair and Cosmetic Medicine Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won\u2010Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Institute of Hair and Cosmetic Medicine Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/70.7.628"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8019.2001.01038.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.032"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14040"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00078.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.1622"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.10.1276"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01781.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.62747"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.111223"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.5764"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01862.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.423"},{"issue":"12","key":"e_1_2_10_15_1","first-page":"860","article-title":"Intralesional triamcinolone acetonide versus topical betamethasone valearate in the management of localized alopecia areata","volume":"25","author":"Devi M","year":"2015","journal-title":"JCPSP"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.82123"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.04.049"},{"issue":"10","key":"e_1_2_10_18_1","first-page":"909","article-title":"Treatment of severe alopecia areata with intralesional steroid injections","volume":"8","author":"Chang KH","year":"2009","journal-title":"JDD"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6398.1015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1985.01660050039009"},{"issue":"2","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2340\/0001555566179180","article-title":"A trial of 1% minoxidil used topically for severe alopecia areata","volume":"66","author":"Vestey JP","year":"1986","journal-title":"Acta Dermato\u2010Venereol"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660350091020"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1985.tb05589.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13049"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200506060-00007"},{"issue":"6","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1001\/archderm.1990.01670300056006","article-title":"Treatment\u2010resistant alopecia areata. 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