{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:25:12Z","timestamp":1778631912005,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T00:00:00Z","timestamp":1497657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Linear immunoglobulin (Ig)A\/G bullous dermatosis (<jats:styled-content style=\"fixed-case\">LAGBD<\/jats:styled-content>) is an autoimmune bullous disease characterized by formation of subepidermal blisters and linear deposition of IgA and IgG antibodies along the basement membrane zone (<jats:styled-content style=\"fixed-case\">BMZ<\/jats:styled-content>). The association between linear IgA bullous dermatosis and ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) is well recognized, but reports of <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">LAGBD<\/jats:styled-content> are lacking. We have reported a 24\u2010year\u2010old man suffering from <jats:styled-content style=\"fixed-case\">LAGBD<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>, which occurred before exacerbations of skin rash. A skin biopsy indicated a subepidermal blister with an infiltration of primarily neutrophils and eosinophils in the dermis. Direct immunofluorescence (<jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>) studies showed a linear deposition of IgA, IgG and C3c. Indirect <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> of human skin revealed IgA and IgG anti\u2010<jats:styled-content style=\"fixed-case\">BMZ<\/jats:styled-content> autoantibodies. Indirect <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> of 1 M NaCl\u2010split human skin demonstrated reactivity of IgA and IgG antibodies at the epidermal side. Immunoblotting showed that IgG antibodies reacted to the <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16a domain and 120\u2010<jats:styled-content style=\"fixed-case\">kD<\/jats:styled-content>a linear IgA dermatosis\u20101, and enzyme\u2010linked immunoassay detected IgG anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230 antibodies. Administration of prednisolone and diaminodiphenyl sulfone (<jats:styled-content style=\"fixed-case\">DDS<\/jats:styled-content>) via the p.o. route improved skin lesions and bowel conditions. These results suggest that the bowel inflammation observed in <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> may have a causative effect of initiation of the immune response to the skin and development of the bullous skin lesions in <jats:styled-content style=\"fixed-case\">LAGBD<\/jats:styled-content>. A combination of <jats:styled-content style=\"fixed-case\">DDS<\/jats:styled-content> and corticosteroid could be a recommended therapeutic option for patients with <jats:styled-content style=\"fixed-case\">LAGBD<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.13934","type":"journal-article","created":{"date-parts":[[2017,6,17]],"date-time":"2017-06-17T23:26:36Z","timestamp":1497741996000},"page":"1295-1298","source":"Crossref","is-referenced-by-count":14,"title":["Linear immunoglobulin A\/G bullous dermatosis associated with ulcerative colitis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7003-4164","authenticated-orcid":false,"given":"Asuka","family":"Onoe","sequence":"first","affiliation":[{"name":"Department of Dermatology Nihon University Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nihon University Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Terui","sequence":"additional","affiliation":[{"name":"Division of Dermatological Science Department of Dermatology Nihon University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine Kurume Japan"},{"name":"Kurume University Institute of Cutaneous Cell Biology Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Kurume University Institute of Cutaneous Cell Biology Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoko","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nihon University Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246933"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01158.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01221.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.5691"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0985"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1684\/ejd.2015.2667","article-title":"Infantile linear IgA\/IgG bullous dermatosis","volume":"26","author":"Izaki S","year":"2016","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2555"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1923"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351427"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.6751622.x"},{"key":"e_1_2_5_12_1","first-page":"48","article-title":"Linear IgA disease and ulcerative colitis","volume":"8","author":"Simone C","year":"1998","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12301"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13872"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06559.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:11:52Z","timestamp":1695535912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,17]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/1346-8138.13934"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13934","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,17]]}}}