{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T11:34:54Z","timestamp":1744716894697,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T00:00:00Z","timestamp":1498780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cholinergic urticaria occasionally occurs in combination with anaphylactic symptoms. However, this has not been widely reported. Herein, we report the case of a 14\u2010year\u2010old Japanese male who was diagnosed with cholinergic urticaria accompanied by anaphylaxis. The patient, who was suffering from atopic dermatitis and bronchial asthma, had developed wheals after exercising or bathing, which would have increased his core body temperature, since summer 2014. He experienced two episodes of severe systemic symptoms and wheal development when he took a bath after eating in December 2014 and the following January. His symptoms included wheezing, numbness of the lips, respiratory distress, blindness and fainting. Laboratory tests revealed the following results: serum IgE level, 7060 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>; titers of specific immunoglobulin E antibodies against <jats:italic>Malassezia<\/jats:italic> and <jats:styled-content style=\"fixed-case\">MGL<\/jats:styled-content>_1304, 31.70 <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content> and 112.5 ng\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>, respectively. A histamine release test against human sweat revealed a class 4 response. Skin prick and intradermal tests against autologous sweat produced immediate\u2010type positive reactions. According to these findings, we diagnosed him with the sweat\u2010hypersensitivity type of cholinergic urticaria accompanied by anaphylaxis. He was successfully treated with lafutidine, a histamine H<jats:sub>2<\/jats:sub> receptor antagonist, in combination with fexofenadine. It is important for dermatologists to be aware that cholinergic urticaria can progress to anaphylaxis.<\/jats:p>","DOI":"10.1111\/1346-8138.13951","type":"journal-article","created":{"date-parts":[[2017,6,30]],"date-time":"2017-06-30T09:26:38Z","timestamp":1498814798000},"page":"1291-1294","source":"Crossref","is-referenced-by-count":5,"title":["Case of cholinergic urticaria accompanied by anaphylaxis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9945-7064","authenticated-orcid":false,"given":"Shigeruko","family":"Iijima","sequence":"first","affiliation":[{"name":"Hanamizuki Clinic Ushiku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Kojo","sequence":"additional","affiliation":[{"name":"Hanamizuki Clinic Ushiku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Takayama","sequence":"additional","affiliation":[{"name":"Hanamizuki Clinic Ushiku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Hiragun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michihiro","family":"Hide","sequence":"additional","affiliation":[{"name":"Department of Dermatology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-OA-0611"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.10.154"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0038-x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-017-0418-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.11.001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.09.021"},{"key":"e_1_2_5_8_1","first-page":"745","article-title":"Anaphylaxislike cholinergic urticaria","volume":"59","author":"Antolin\u2010Amerigo D","year":"2013","journal-title":"Can Fam Physician"},{"key":"e_1_2_5_9_1","first-page":"241","article-title":"Cholinergic urticaria with anaphylaxis: hazardous duty of a deployed US marine","volume":"95","author":"Handfield KS","year":"2015","journal-title":"Cutis"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.024"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.03.047"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2015.03.003"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13574"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.02.001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.S3.1601"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.13951","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.13951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:11:45Z","timestamp":1695535905000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.13951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,30]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/1346-8138.13951"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.13951","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2017,6,30]]}}}