{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:43:43Z","timestamp":1790775823048,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81271758 and 81472887"],"award-info":[{"award-number":["81271758 and 81472887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>To determine the levels and sources of chemokines in the serum and epidermis of vitiligo patients, we examined 80 active patients, 80 stable patients and 40 healthy controls. First, the serum levels of candidate chemokines were measured by Luminex assay, and levels of CCR<\/jats:styled-content>5, CXCR<\/jats:styled-content>1 and CXCR<\/jats:styled-content>3 were measured in peripheral mononuclear cells (PMBC<\/jats:styled-content>) by flow cytometry. Then, the local epidermis levels of elevated chemokines in vitiligo were tested by Luminex. Finally, the mRNA<\/jats:styled-content> and protein expression levels of elevated chemokines in HaCaT cells stimulated with interferon (IFN<\/jats:styled-content>)\u2010\u03b3 or tumor necrosis factor (TNF<\/jats:styled-content>)\u2010\u03b1 were tested by quantitative real\u2010time polymerase chain reaction and Luminex. The serum levels of CCL<\/jats:styled-content>5, CXCL<\/jats:styled-content>8 and CXCL<\/jats:styled-content>10 in active vitiligo were significantly elevated compared with those in stable vitiligo patients. Furthermore, the levels of CCL<\/jats:styled-content>3 and CCL<\/jats:styled-content>4 had weak and positive correlations with the Vitiligo Area Scoring Index. In the peripheral blood of active vitiligo patients, the percentages of CD<\/jats:styled-content>3+<\/jats:sup>CD<\/jats:styled-content>8+<\/jats:sup>CCR<\/jats:styled-content>5+<\/jats:sup> and CD<\/jats:styled-content>3+<\/jats:sup>CD<\/jats:styled-content>8+<\/jats:sup>CXCR<\/jats:styled-content>3+<\/jats:sup> T cells were significantly increased compared with those in stable vitiligo and healthy controls. In the epidermis of lesions, the expression levels of CCL<\/jats:styled-content>5 and CXCL<\/jats:styled-content>10 in active vitiligo were significantly increased. In addition, the mRNA<\/jats:styled-content> and protein levels of CCL<\/jats:styled-content>5, CXCL<\/jats:styled-content>8 and CXCL<\/jats:styled-content>10 were significantly elevated in HaCaT cells after stimulation with TNF<\/jats:styled-content>\u2010\u03b1 or IFN<\/jats:styled-content>\u2010\u03b3. The CCR<\/jats:styled-content>5\/CCL<\/jats:styled-content>5 and CXCR<\/jats:styled-content>3\/CXCL<\/jats:styled-content>10 axes may play an important role in the progression and maintenance of vitiligo. Moreover, keratinocytes stimulated with TNF<\/jats:styled-content>\u2010\u03b1 and IFN<\/jats:styled-content>\u2010\u03b3 may be a primary source of CCL<\/jats:styled-content>5 and CXCL<\/jats:styled-content>10.<\/jats:p>","DOI":"10.1111\/1346-8138.14004","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T13:08:37Z","timestamp":1510146517000},"page":"31-38","source":"Crossref","is-referenced-by-count":40,"title":["Role of chemokines and the corresponding receptors in vitiligo: A pilot study"],"prefix":"10.1111","volume":"45","author":[{"given":"Lingling","family":"Yang","sequence":"first","affiliation":[{"name":"Dermatology The Third People's Hospital of Hangzhou Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailing","family":"Yang","sequence":"additional","affiliation":[{"name":"Dermatology Third Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 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