{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:36:50Z","timestamp":1774611410728,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence has emerged about the relationship between atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) and autoimmune diseases, but the underlying mechanism of this association is complex and still unclear. Recent epidemiological data from the published work suggest a positive correlation. The aim of this review is to analyze the frequency of co\u2010occurrence of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and autoimmune diseases. Our systematic review included 22 articles from PubMed describing the reciprocal association between <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and autoimmune diseases. Although not all the studies achieved statistically significant results, patients suffering from autoimmune diseases involving skin and intestinal mucosa, such as vitiligo, alopecia areata, celiac disease and inflammatory bowel diseases, showed a higher risk to have <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> as comorbidity. In contrast, patients with rheumatological autoimmune disorders did not show a significant correlation with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. By analyzing the occurrence of autoimmune disorders in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, we confirmed a positive correlation between <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and autoimmune diseases involving skin and intestinal mucosa, but also with systemic lupus erythematosus, while the association between <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and type 1 diabetes, autoimmune thyroiditis and rheumatoid arthritis showed conflicting results. Further investigations are need to explain the mechanism underlying the observed comorbidity between <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and autoimmune diseases and to develop targeted prevention strategies and treatment.<\/jats:p>","DOI":"10.1111\/1346-8138.14031","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T05:02:37Z","timestamp":1505797357000},"page":"1341-1348","source":"Crossref","is-referenced-by-count":35,"title":["Autoimmune diseases involving skin and intestinal mucosa are more frequent in adolescents and young adults suffering from atopic dermatitis"],"prefix":"10.1111","volume":"44","author":[{"given":"Francesca","family":"Cipriani","sequence":"first","affiliation":[{"name":"Pediatric Unit Department of Medical and Surgical Sciences University of Bologna Bologna 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