{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:21:32Z","timestamp":1780615292149,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T00:00:00Z","timestamp":1505692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apocrine hidrocystoma (<jats:styled-content style=\"fixed-case\">AHC<\/jats:styled-content>) is a benign cystic lesion arising from apocrine glands and frequently presents as a blue hae with a whitish gloss. It has been reported that the amount of lipofuscin and the degree of its oxidation determines the pigmentation of <jats:styled-content style=\"fixed-case\">AHC<\/jats:styled-content>. However, little is known about the correlation between clinical color and lipofuscin granules. In this study, we histopathologically investigated three cases of <jats:styled-content style=\"fixed-case\">AHC<\/jats:styled-content> and statistically analyzed the quantitative correlation between the clinical color tone and the amount of cytoplasmic lipofuscin deposits. The color tone was quantified as the mean gray value using Image J software. Statistical analysis showed a negative correlative tendency (<jats:italic>P<\/jats:italic> = 0.09) between the color tone and the amount of lipofuscin. Our study suggests that the color tone of <jats:styled-content style=\"fixed-case\">AHC<\/jats:styled-content> is associated with the amount of lipofuscin.<\/jats:p>","DOI":"10.1111\/1346-8138.14037","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T04:58:40Z","timestamp":1505797120000},"page":"91-94","source":"Crossref","is-referenced-by-count":3,"title":["Lipofuscin deposition causes the pigmentation of apocrine hidrocystoma"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4232-2943","authenticated-orcid":false,"given":"Shinya","family":"Kitamura","sequence":"first","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-7600","authenticated-orcid":false,"given":"Teruki","family":"Yanagi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8855-3288","authenticated-orcid":false,"given":"Keisuke","family":"Imafuku","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1964.01600030024005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)70177-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1001\/archderm.1974.01630050046010","article-title":"Apocrine hidrocystoma (cystademnoma)","volume":"109","author":"Smith JD","year":"1974","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090060156041"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182a23a87"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-370469-6.00009-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"e29470","DOI":"10.1371\/journal.pone.0029740","article-title":"Color\u2010to\u2010grayscale: does the method matter in image recognition?","volume":"7","author":"Kanan C","year":"2012","journal-title":"PLoS ONE"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-411-1_13"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2005.12.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.116820"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02484.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/1346-8138.13725","article-title":"Estimating melanin location in the pigmented skin lesions by hue\u2010saturation\u2010lightness color space values of dermoscopic images","volume":"31","author":"Sakai H","year":"2017","journal-title":"J Dermatol"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:23:25Z","timestamp":1695572605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/1346-8138.14037"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14037","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,18]]}}}