{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:46:51Z","timestamp":1790023611081,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:00:00Z","timestamp":1506297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>\n \n Mucosal melanoma is a rare aggressive cancer with a very poor prognosis. Clinical and pathological characteristics of mucosal melanoma differ from those of cutaneous melanoma and there are no established management guidelines for mucosal melanoma. Complete surgical excision is one of the most effective treatments for localized lesions, while targeted therapies and immunotherapies, such as monoclonal antibodies that target cytotoxic T\u2010lymphocyte\u2010associated molecule\u20104, and the programmed death (\n PD<\/jats:styled-content>\n )\u20101\/\n PD<\/jats:styled-content>\n \u2010ligand 1 pathway inhibitors, are treatment options for unresectable or metastatic lesions. Here, we describe the case of a patient with oral mucosal melanoma with multiple metastases. In our case, local injection of interferon (\n IFN<\/jats:styled-content>\n )\u2010\u03b2 with dacarbazine\u2013nimustine\u2013vincristine therapy provided antitumor effects on an invasive tumor on the upper gingiva. Nivolumab therapy produced complete remission of lymph node and bone metastases. In contrast, the remaining\n in situ<\/jats:italic>\n portion of oral mucosal melanoma on the hard palate was refractory to\n IFN<\/jats:styled-content>\n \u2010\u03b2 monotherapy and nivolumab therapy. However, after administration of nivolumab, peritumoral injection of\n IFN<\/jats:styled-content>\n \u2010\u03b2 showed rapid therapeutic effects. Our case suggested that nivolumab upregulated the antitumor effects of\n IFN<\/jats:styled-content>\n \u2010\u03b2, which induced the recruitment of\n CD<\/jats:styled-content>\n 8\n +<\/jats:sup>\n T cells into the tumor microenvironment contributing to the deletion of tumor cells. Combination therapy of\n IFN<\/jats:styled-content>\n \u2010\u03b2 and nivolumab may be a potential treatment option for patients with oral mucosal melanoma.\n <\/jats:p>","DOI":"10.1111\/1346-8138.14041","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T01:21:36Z","timestamp":1506302496000},"page":"87-90","source":"Crossref","is-referenced-by-count":11,"title":["Synergistic effects of interferon\u2010beta and nivolumab in oral mucosal melanoma"],"prefix":"10.1111","volume":"45","author":[{"given":"Takayuki","family":"Fusumae","sequence":"first","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-1947","authenticated-orcid":false,"given":"Koji","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binluen","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.031"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.01.019"},{"issue":"15","key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/jnci\/84.15.1185","article-title":"Antiproliferative potencies of interferons on melanoma cell lines and xenografts: higher efficacy of interferon beta","volume":"84","author":"Johns TG","year":"1992","journal-title":"J Natl Cancer 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