{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:35:10Z","timestamp":1787564110353,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Heparin\u2010binding epidermal growth factor (\n                    <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                    )\u2010like growth factor (\n                    <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                    ) is a member of the\n                    <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                    family growth factors, which affects multiple aspects of the wound healing process such as epithelialization, wound contraction and angiogenesis. In our study, we measured the serum\n                    <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                    levels of 51 systemic sclerosis (\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c) patients, which showed a significant increase compared with those of 20 normal subjects. Further analysis revealed a positive correlation between the\n                    <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                    level and pulmonary ground\u2010glass score but no correlation between the former and pulmonary fibrosis score. Other findings include: a significant increase of serum sialylated carbohydrate antigen\n                    <jats:styled-content style=\"fixed-case\">KL<\/jats:styled-content>\n                    \u20106 levels and significant shortness of disease duration in the diffuse cutaneous\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c patients with elevated\n                    <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                    levels; and significantly higher\n                    <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                    levels in the presence of Raynaud's phenomenon, in that of telangiectasia, and in the absence of contracture of phalanges in all\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c patients. We then evaluated\n                    <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EGF mRNA<\/jats:styled-content>\n                    levels of fibroblasts harvested from skin samples of the\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c patients and those of foreskin\u2010derived fibroblasts treated with transforming growth factor\u2010\u03b2, both of which were significantly higher than each control. In conclusion, we speculate that\n                    <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content>\n                    plays a pro\u2010inflammatory role in the active skin and lung lesions of\n                    <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                    c.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.14088","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T07:46:40Z","timestamp":1508226400000},"page":"182-188","source":"Crossref","is-referenced-by-count":10,"title":["Possible pro\u2010inflammatory role of heparin\u2010binding epidermal growth factor\u2010like growth factor in the active phase of systemic sclerosis"],"prefix":"10.1111","volume":"45","author":[{"given":"Megumi","family":"Hirabayashi","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5560-9778","authenticated-orcid":false,"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo 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