{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:10:38Z","timestamp":1760346638597,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T00:00:00Z","timestamp":1508889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Between 2008 and 2015, 462 newly\u2010diagnosed adult T\u2010cell leukemia\/lymphoma (<jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>) patients with cutaneous involvement were found from the nationwide registry for Japanese patients with cutaneous lymphoma, of which 391 were selected for the study. They ranged in age from 28 to 93 years (median, 69 years), and included 215 men and 176 women (male : female ratio = 1.2). The 391 patients comprised 193 (50%) with smoldering type, 52 (13%) with chronic type, 44 (11%) with lymphoma type and 102 (26%) with acute type. The total number of patients in Kyushu\/Okinawa was 8.8\u2010times higher than that in Kanto, which was set as the reference value, while the estimated prevalence of human T\u2010lymphotropic virus 1 (<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101) carriers in Kyushu\/Okinawa has been reported to be only 2.5\u2010times higher than that in Kanto. In this study, the annual incidence of <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> per 100 000 residents in Kyushu\/Okinawa was 32\u2010times higher than that in Kanto. Our results indicated the higher incidence rate of <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> in the endemic area than those in the non\u2010endemic areas in Japan, compared with the regional differences of <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 prevalence determined by serological <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 screening for blood donors. In addition, this analysis revealed that regional differences of mycosis fungoides\/S\u00e9zary syndrome incidence rates were very small compared with those of <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.14100","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T10:22:37Z","timestamp":1508926957000},"page":"58-63","source":"Crossref","is-referenced-by-count":4,"title":["Regional incidences of adult T\u2010cell leukemia\/lymphoma with cutaneous involvement in Japan"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-5707","authenticated-orcid":false,"given":"Toshihisa","family":"Hamada","sequence":"first","affiliation":[{"name":"Departments of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"},{"name":"The Japanese Study Group for Cutaneous Lymphomas The Japanese Skin Cancer Society Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayato","family":"Nomura","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Iwatsuki","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"},{"name":"The Japanese Study Group for Cutaneous Lymphomas The Japanese Skin Cancer Society Kumamoto 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