{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:40:35Z","timestamp":1768282835753,"version":"3.49.0"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>A 92\u2010year\u2010old man developed an erythematous eruption on the trunk and extremities with numerous pustules accompanied by fever. He had never experienced pustular eruption or been diagnosed with psoriasis previously. Skin biopsy revealed Kogoj's spongiform pustule, and he was diagnosed with generalized pustular psoriasis (GPP<\/jats:styled-content>). Genomic DNA<\/jats:styled-content> was extracted from his peripheral blood and the sequence of IL<\/jats:styled-content>36RN<\/jats:styled-content><\/jats:italic> gene was analyzed, which revealed a p.Arg10X homozygous mutation. Several cases of elderly\u2010onset GPP<\/jats:styled-content> have been reported, however, this is the oldest case of GPP<\/jats:styled-content>. The existence of splice variants of IL<\/jats:styled-content>36RN<\/jats:styled-content><\/jats:italic> was suspected, but we could not detect any splice variants of IL<\/jats:styled-content>36RN<\/jats:styled-content><\/jats:italic> in this case or in a healthy control from peripheral blood samples.<\/jats:p>","DOI":"10.1111\/1346-8138.14132","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T11:07:04Z","timestamp":1512644824000},"page":"326-328","source":"Crossref","is-referenced-by-count":2,"title":["Generalized pustular psoriasis in a 92\u2010year\u2010old man with a homozygous nonsense mutation in IL<\/scp>36RN<\/scp><\/i>"],"prefix":"10.1111","volume":"45","author":[{"given":"Yoshitaka","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1086-1803","authenticated-orcid":false,"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7938-1947","authenticated-orcid":false,"given":"Koji","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamitaro","family":"Ohtsuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.230"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10953.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.07.022"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000438505"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.219089"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2001.028003113.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04129.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2012.04407.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.354"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T04:01:45Z","timestamp":1694491305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/1346-8138.14132"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14132","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,7]]}}}