{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:20:25Z","timestamp":1769836825471,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We recently identified the efficacy and safety of a botulinum toxin (<jats:styled-content style=\"fixed-case\">BTX<\/jats:styled-content>)\u2010A\/B in Raynaud's phenomenon (<jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>) and digital ulcers (<jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>) in Japanese patients with systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c). Detailed assessments of peripheral vascular disorder using angiography and dermoscopic images of nail fold capillaries have not been performed previously. This study aimed to evaluate the effect of <jats:styled-content style=\"fixed-case\">BTX<\/jats:styled-content>\u2010B on <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c\u2010associated peripheral vascular disorder. Two <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients who suffered with <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content> were treated with a <jats:styled-content style=\"fixed-case\">BTX<\/jats:styled-content>\u2010B injection, and thereafter the symptoms of <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> were improved and <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content> healed in both patients. Furthermore, angiography showed an increased blood flow to the palm and fingers, and dermoscopic images of nail fold capillary changes showed improvement. These results suggest that a <jats:styled-content style=\"fixed-case\">BTX<\/jats:styled-content>\u2010B injection may increase peripheral blood flow and improve <jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients.<\/jats:p>","DOI":"10.1111\/1346-8138.14140","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T07:32:44Z","timestamp":1511335964000},"page":"349-352","source":"Crossref","is-referenced-by-count":24,"title":["Successful treatment of Raynaud's phenomenon and digital ulcers in systemic sclerosis patients with botulinum toxin B injection: Assessment of peripheral vascular disorder by angiography and dermoscopic image of nail fold capillary"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-0669","authenticated-orcid":false,"given":"Sei\u2010ichiro","family":"Motegi","sequence":"first","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohisa","family":"Ishibuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi 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