{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:41:51Z","timestamp":1788309711780,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T00:00:00Z","timestamp":1513209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydroxychloroquine (<jats:styled-content style=\"fixed-case\">HCQ<\/jats:styled-content>) is an effective treatment of lupus erythematosus. Although adverse effects, mainly gastrointestinal and cutaneous manifestations, are rare, they may result in the cessation of medication in some patients with severe reactions. Therefore, the evaluation of a patient's condition is important for a dermatologist to decide whether to cease or continue <jats:styled-content style=\"fixed-case\">HCQ<\/jats:styled-content>. We herein report a case of a 36\u2010year\u2010old Japanese woman with systemic lupus erythematosus and cutaneous eruptions caused by the p.o. administration of <jats:styled-content style=\"fixed-case\">HCQ<\/jats:styled-content>. Because she wanted to continue the medication and had only mild cutaneous eruptions without any adverse effects in other organs, we continued <jats:styled-content style=\"fixed-case\">HCQ<\/jats:styled-content> with careful monitoring. All cutaneous eruptions disappeared within 1\u00a0week. We also reviewed published case reports on skin lesions that developed after <jats:styled-content style=\"fixed-case\">HCQ<\/jats:styled-content> treatments, and propose strategies for early cutaneous eruptions after <jats:styled-content style=\"fixed-case\">HCQ<\/jats:styled-content> treatments. When the cutaneous reactions are mild without any reactions in other organs, withdrawal of the drug is not required. However, when cutaneous eruptions are accompanied by some common reactions, <jats:styled-content style=\"fixed-case\">HCQ<\/jats:styled-content> needs to be stopped for a period of time and may subsequently be carefully re\u2010administrated.<\/jats:p>","DOI":"10.1111\/1346-8138.14156","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T05:52:58Z","timestamp":1513230778000},"page":"344-348","source":"Crossref","is-referenced-by-count":19,"title":["Early cutaneous eruptions after oral hydroxychloroquine in a lupus erythematosus patient: A case report and review of the published work"],"prefix":"10.1111","volume":"45","author":[{"given":"Tomoko","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department ofDermatology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhung Thi My","family":"Ly","sequence":"additional","affiliation":[{"name":"Department ofDermatology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-4952","authenticated-orcid":false,"given":"Naotomo","family":"Kambe","sequence":"additional","affiliation":[{"name":"Department ofDermatology Kansai Medical University Hirakata Japan"},{"name":"Department ofAllergy Center Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyen Thi Hong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department ofDermatology Kansai Medical University Hirakata Japan"},{"name":"Department of Dermatology and Venereology University of Medicine and Pharmacy at Ho Chi Minh City Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Ueda\u2010Hayakawa","sequence":"additional","affiliation":[{"name":"Department ofDermatology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonsu","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department ofDermatology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1191\/096120301669779293"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.03.007"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.9.1231"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40018"},{"key":"e_1_2_5_6_1","first-page":"2179","article-title":"Diagnosis of systemic\u00a0lupus erythematosus","volume":"68","author":"Gill JM","year":"2003","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00131.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012433901-9\/50032-6"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000438787"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10565"},{"key":"e_1_2_5_11_1","first-page":"814","article-title":"Desensitization to hydroxychloroquine\u2013experience of 4 patients","volume":"33","author":"Mates M","year":"2006","journal-title":"J Rheumatol"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T04:01:55Z","timestamp":1694491315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/1346-8138.14156"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14156","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]}}}