{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:32:13Z","timestamp":1763037133311,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T00:00:00Z","timestamp":1512604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health, Labor and Welfare of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thymoma\u2010associated graft\u2010versus\u2010host disease (<jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>)\u2010like disease is a rare paraneoplastic disease seen in patients with thymoma. Here, we describe the first case of thymoma\u2010associated <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>\u2010like disease localized to the skin that was successfully improved by a combination of systemic corticosteroids and whole\u2010body narrowband ultraviolet (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> phototherapy. The patient had developed toxic epidermal necrolysis\u2010like erosive skin lesions over the whole body. Although systemic corticosteroids were effective up to a point, we were unable to begin the steroid taper. The addition of systemic narrowband <jats:styled-content style=\"fixed-case\">UV\u2010B<\/jats:styled-content> phototherapy improved the skin manifestation of this disease, allowing corticosteroids to be reduced to a third of the original dose. Histopathologically, it was confirmed that the proportion of Foxp3\u2010positive lymphocytes in the skin increased after narrowband <jats:styled-content style=\"fixed-case\">UV\u2010B<\/jats:styled-content> irradiation. We propose that whole\u2010body narrowband <jats:styled-content style=\"fixed-case\">UV\u2010B<\/jats:styled-content> phototherapy is a good therapeutic option for the skin manifestation of thymoma\u2010associated <jats:styled-content style=\"fixed-case\">GVHD<\/jats:styled-content>\u2010like disease.<\/jats:p>","DOI":"10.1111\/1346-8138.14176","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T11:05:55Z","timestamp":1512644755000},"page":"479-482","source":"Crossref","is-referenced-by-count":8,"title":["Case of thymoma\u2010associated cutaneous graft\u2010versus\u2010host disease\u2010like disease successfully improved by narrowband ultraviolet <scp>B<\/scp> phototherapy"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-0551","authenticated-orcid":false,"given":"Kazuki","family":"Yatsuzuka","sequence":"first","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiko","family":"Tohyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Sayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03505-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2007.08.010"},{"issue":"6","key":"e_1_2_6_4_1","first-page":"818","article-title":"Cutaneous manifestations of thymoma\u2010associated multi\u2010organ autoimmunity: a fatal sign","volume":"96","author":"Muramatsu K","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12642"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04472.x"},{"key":"e_1_2_6_7_1","first-page":"352","article-title":"The thymic orchestration involving aire, miRNAs, and cell\u2010cell interactions during the induction of central tolerance","volume":"6","author":"Passos GA","year":"2015","journal-title":"Front Immunol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12960"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa7017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1577"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1530-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400985"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2716"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T01:09:32Z","timestamp":1695517772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,7]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/1346-8138.14176"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14176","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2017,12,7]]}}}