{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:33:43Z","timestamp":1790386423383,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Education, Culture, Sports and Technology in Japan","award":["16K10146"],"award-info":[{"award-number":["16K10146"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>Interleukin (IL<\/jats:styled-content>)\u201036\u03b3 is expressed by keratinocytes and functions as a key initiator of inflammation in the skin. IL<\/jats:styled-content>\u201036\u03b3 expression is enhanced by tumor necrosis factor\u2010\u03b1 and IL<\/jats:styled-content>\u201017A, having a strong association with psoriasis. In this study, we examined the role of IL<\/jats:styled-content>\u201036\u03b3 in atopic dermatitis (AD<\/jats:styled-content>) and mycosis fungoides (MF<\/jats:styled-content>)\/S\u00e9zary syndrome (SS<\/jats:styled-content>). Serum levels of IL<\/jats:styled-content>\u201036\u03b3 in AD<\/jats:styled-content> patients and MF<\/jats:styled-content>\/SS<\/jats:styled-content> patients were elevated compared with those of healthy controls. Importantly, serum IL<\/jats:styled-content>\u201036\u03b3 levels in AD<\/jats:styled-content> patients positively correlated with Eczema Area and Severity Index and those of MF<\/jats:styled-content>\/SS<\/jats:styled-content> patients positively correlated with serum soluble IL<\/jats:styled-content>\u20102 receptor levels. IL<\/jats:styled-content>\u201036\u03b3 mRNA<\/jats:styled-content> levels in AD<\/jats:styled-content> skin and MF<\/jats:styled-content>\/SS<\/jats:styled-content> skin were significantly higher than those of normal skin. IL<\/jats:styled-content>\u201036\u03b3 mRNA<\/jats:styled-content> levels in MF<\/jats:styled-content>\/SS<\/jats:styled-content> skin positively correlated with IL<\/jats:styled-content>\u201017A mRNA<\/jats:styled-content> levels. Immunohistochemical staining revealed that IL<\/jats:styled-content>\u201036\u03b3 was highly expressed in keratinocytes in lesional skin of AD<\/jats:styled-content> and MF<\/jats:styled-content>\/SS<\/jats:styled-content>. Taken together, our study demonstrated that IL<\/jats:styled-content>\u201036\u03b3 expression was increased in sera and skin of patients with AD<\/jats:styled-content> and MF<\/jats:styled-content>\/SS<\/jats:styled-content> as was reported in psoriatic patients.<\/jats:p>","DOI":"10.1111\/1346-8138.14198","type":"journal-article","created":{"date-parts":[[2018,1,4]],"date-time":"2018-01-04T03:49:02Z","timestamp":1515037742000},"page":"468-471","source":"Crossref","is-referenced-by-count":23,"title":["Increased interleukin\u201036\u03b3 expression in skin and sera of patients with atopic dermatitis and mycosis fungoides\/S\u00e9zary syndrome"],"prefix":"10.1111","volume":"45","author":[{"given":"Sayaka","family":"Otobe","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo 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