{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:41:11Z","timestamp":1792698071891,"version":"4.5.0"},"reference-count":105,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T00:00:00Z","timestamp":1516406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content> collagen (<jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>7), a major component of anchoring fibrils in the epidermal basement membrane zone, has been characterized as a defective protein in dystrophic epidermolysis bullosa and as an autoantigen in epidermolysis bullosa acquisita. Although <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>7 is produced and secreted by both epidermal keratinocytes and dermal fibroblasts, the role of <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>7 with regard to the epidermis is rarely discussed. This review focuses on <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>7 physiology and pathology as it pertains to epidermal keratinocytes. We summarize the current knowledge of <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>7 production and trafficking, its involvement in keratinocyte dynamics, and epidermal carcinogenesis in <jats:styled-content style=\"fixed-case\">COL<\/jats:styled-content>7 deficiency and propose possible solutions to unsolved issues in this field.<\/jats:p>","DOI":"10.1111\/1346-8138.14222","type":"journal-article","created":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T06:16:42Z","timestamp":1516429002000},"page":"515-521","source":"Crossref","is-referenced-by-count":32,"title":["Epidermal aspects of type VII collagen: Implications for dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita"],"prefix":"10.1111","volume":"45","author":[{"given":"Mika","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-6366","authenticated-orcid":false,"given":"Ken","family":"Natsuga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Shinkuma","sequence":"additional","affiliation":[{"name":"Division of Dermatology Niigata University Graduate School of Medical and Dental Sciences Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3902"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1994.1239"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.903"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0593-62"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1193-287"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.09.035"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21551"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.149"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.356"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923-1811(93)90038-Q"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09508.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.03.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-132"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.370"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2009.10.011"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S54681"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150316122502"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.11.3168"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1016\/S0021-9258(19)57262-3","article-title":"The tissue form of type VII collagen is an antiparallel dimer","volume":"261","author":"Morris NP","year":"1986","journal-title":"J Biol Chem"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.103.4.1577"},{"key":"e_1_2_6_22_1","first-page":"753","article-title":"Most anchoring fibrils in human skin originate and terminate in the lamina densa","volume":"76","author":"Shimizu H","year":"1997","journal-title":"Lab Invest"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31984-1"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M709452200"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.23.14516"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.131.2.551"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi034925d"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116774"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.02.002"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.138.3.719"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802415200"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115557"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.111.5.2109"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700230"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12474424"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112.21.3641"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090347"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013002"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.12.025"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1609571113"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201608080"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02784"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10982"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1985.tb51156.x"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004911"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2014.08.014"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201311112"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.168021"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13132"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00394.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.5"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26635"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018218"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253734"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.029"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005124"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad4395"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1348"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.038"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1041"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003440200"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34292"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI68127"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.00316.x"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)81118-0"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.117.3.679"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12614773"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13053"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1747.2003.12640.x"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0910501"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1016753108"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-161299"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000044107"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.15588"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1504"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2013.11.001"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.038"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24487"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81894-2"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.64"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.118"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09118.x"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2468-2"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.04.014"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.06.010"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)62326-8"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100332108"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009342"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.523"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.346"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1512028113"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.87"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106209"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12493"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700878"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.180"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.128454"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.042895"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12715"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv293"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.08.004"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/307658a0"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601894"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1099"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1614775114"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.002"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14222","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:16:47Z","timestamp":1695557807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,20]]},"references-count":105,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/1346-8138.14222"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14222","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,20]]}}}