{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:08:43Z","timestamp":1780708123067,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,21]],"date-time":"2018-01-21T00:00:00Z","timestamp":1516492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Vascular tumors associated with Kasabach\u2013Merritt phenomenon (<jats:styled-content style=\"fixed-case\">KMP<\/jats:styled-content>) are life\u2010threatening and the mortality is as high as 10\u201330%. Steroids are considered the primary choice for drug therapy. However, there are many steroid\u2010resistant cases. In the present study, analyzed data are presented to support the use of sirolimus in clinical practise for the treatment of corticosteroid\u2010resistant vascular tumors with <jats:styled-content style=\"fixed-case\">KMP<\/jats:styled-content> in eight infants between June 2015 and April 2017 in a single hospital. The time to initial response was 6.8 \u00b1 2.7 days. The average stabilization time for the platelet count was 19.1 \u00b1 8.5 days. At the time of publication, the average duration of sirolimus treatment was 14.1 \u00b1 4.0 months, and the average time for sirolimus treatment as a single agent was 12.6 \u00b1 4.2 months. The side\u2010effects were tolerable and included oral ulcer, fever, pain, skin rash and transient ascension of serum transaminase and cholesterol. Our study indicated that sirolimus therapy is an effective and safe method for the treatment of corticosteroid resistant vascular tumors associated with <jats:styled-content style=\"fixed-case\">KMP<\/jats:styled-content> in infants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1346-8138.14231","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:09:42Z","timestamp":1516633782000},"page":"580-583","source":"Crossref","is-referenced-by-count":26,"title":["Successful management of steroid\u2010resistant vascular tumors associated with the Kasabach\u2013Merritt phenomenon using sirolimus"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-304X","authenticated-orcid":false,"given":"Xiaoyun","family":"Tan","sequence":"first","affiliation":[{"name":"Guangzhou Women and Children's Medical Center Guangzhou Medical University China"},{"name":"Department of Interventional Therapy and Vascular Anomalies Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4135-5900","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center Guangzhou Medical University China"},{"name":"Department of Interventional Therapy and Vascular Anomalies Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center Guangzhou Medical University China"},{"name":"Department of Interventional Therapy and Vascular Anomalies Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center Guangzhou Medical University China"},{"name":"Department of Interventional Therapy and Vascular Anomalies Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center Guangzhou Medical University China"},{"name":"Department of Interventional Therapy and Vascular Anomalies Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejun","family":"Xia","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children's Medical Center Guangzhou Medical University China"},{"name":"Department of Interventional Therapy and Vascular Anomalies Guangzhou Women and Children's Medical Center Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.06.044"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.03.080"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2015.12.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318281558e"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25296"},{"key":"e_1_2_6_7_1","first-page":"881","article-title":"New guidelines to evaluate the response to treatment in solid tumors","volume":"87","author":"Duffaud F","year":"2000","journal-title":"Bull Cancer"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.12.049"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200208000-00010"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-012-2042-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1372587"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-013-1549-3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3257"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12852"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2006.00515.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100391"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:17:00Z","timestamp":1695557820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,21]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/1346-8138.14231"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14231","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,21]]}}}