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We examined the effects of cholecalciferol on <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> vitiligo in a blinded randomized clinical trial. Forty\u2010eight female <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> vitiligo patients were recruited for the trial and were randomized into two groups: the vitamin D (<jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>)\u2010intervention group that received daily 5000\u00a0IU cholecalciferol for 5\u00a0months and the control group. Three blinded investigators scored vitiligo improvement by comparing photographic images of baseline and at 5\u2010month observation. Serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D3 of <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> vitiligo patients was not significantly different from age\u2010matched healthy volunteers. Twenty\u2010two in the <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>\u2010intervention group and 23 in the control group completed the 5\u2010month observation. Serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D3 levels were significantly increased after the 5\u2010month <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> intervention, while the control group did not change. The improvement scores were significantly higher in the <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>\u2010intervention group than the control group. The improvement scores were positively correlated with the serum 25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)D3 levels after the 5\u2010month intervention period but not before the treatment. This blinded randomized clinical trial showed favor in administrating 5000\u00a0IU cholecalciferol daily to <jats:styled-content style=\"fixed-case\">RD<\/jats:styled-content> vitiligo patients.<\/jats:p>","DOI":"10.1111\/1346-8138.14244","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T05:56:41Z","timestamp":1517810201000},"page":"456-462","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of oral cholecalciferol on rhododendrol\u2010induced vitiligo: A blinded randomized clinical trial"],"prefix":"10.1111","volume":"45","author":[{"given":"Akiko","family":"Watabe","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5495-4956","authenticated-orcid":false,"given":"Kenshi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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