{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:25:15Z","timestamp":1781360715641,"version":"3.54.1"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,6]],"date-time":"2018-02-06T00:00:00Z","timestamp":1517875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) is an acquired autoimmune blistering disease in which autoantibodies against epitopes in the basement membrane zone of the skin such as <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 or <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>230 are produced. Dipeptidyl peptidase (<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>)\u20104 inhibitors have become commonly used to treat diabetes. As <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitors are more commonly prescribed for diabetes, <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> related to <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitors has been reported and has attracted attention. Therefore, we retrospectively investigated patients who were diagnosed with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in order to examine characteristics of <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitor\u2010related <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (nine patients; median age, 85\u00a0years) in comparison with non\u2010<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitor\u2010related <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (21; median age, 85\u00a0years). There was no significant difference in Bullous Pemphigoid Disease Area Index between <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitor\u2010related <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients and non\u2010<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitor\u2010related <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients, except for erosions\/blisters score in mucosa. Laboratory tests revealed no significant differences between <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitor\u2010related <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients and non\u2010<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitor\u2010related <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients in total white blood cell count, eosinophil count, neutrophil count and the\u00a0titer of anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 antibody. The number of eosinophils infiltrating into the skin was significantly lower in patients with <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4 inhibitor\u2010related <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> than in patients with non\u2010<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4 inhibitor\u2010related <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. Our results showed that <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitor\u2010related <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> has some distinct pathological characteristics from <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> not associated with <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitor.<\/jats:p>","DOI":"10.1111\/1346-8138.14245","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T04:36:41Z","timestamp":1517978201000},"page":"596-599","source":"Crossref","is-referenced-by-count":58,"title":["Decrease in eosinophils infiltrating into the skin of patients with dipeptidyl peptidase\u20104 inhibitor\u2010related bullous pemphigoid"],"prefix":"10.1111","volume":"45","author":[{"given":"Chika","family":"Chijiwa","sequence":"first","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine Tokyo 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