{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:49:22Z","timestamp":1759942162830,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,11]],"date-time":"2018-02-11T00:00:00Z","timestamp":1518307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report two rare cases of childhood epilepsy patients who developed ethosuximide\u2010induced Stevens\u2013Johnson syndrome (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>). Unlike typical <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>, the initial eruption of both patients presented well\u2010demarcated, infiltrating firm papules mainly on the cheeks and the extensor aspects of the arms (case 1), and multiple vesicles on the soles and oral aphthosis (case 2), which closely mimicked viral exanthema. We diagnosed both patients with ethosuximide\u2010induced <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>, based on the dosing period and the positive results of drug\u2010induced lymphocyte stimulation test. Systemic corticosteroids are usually selected as a standard therapy for <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>, despite controversial results regarding their effectiveness. In case 1, an i.v. pulse therapy of methylprednisolone (30 mg\/kg, 3 days consecutively) was initiated on day 7 from the onset of illness, and an i.v. immunoglobulin (400 mg\/kg, 5 days consecutively) was added the following day. In case 2, an i.v. prednisone treatment (1 mg\/kg, for 1 week) was initiated on day 4 from the onset. Eventually, the early therapeutic interventions resulted in good outcomes in both patients.<\/jats:p>","DOI":"10.1111\/1346-8138.14253","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T02:02:43Z","timestamp":1518400963000},"page":"592-595","source":"Crossref","is-referenced-by-count":7,"title":["Ethosuximide\u2010induced Stevens\u2013Johnson syndrome: Beneficial effect of early intervention with high\u2010dose corticosteroid therapy"],"prefix":"10.1111","volume":"45","author":[{"given":"Kota","family":"Tachibana","sequence":"first","affiliation":[{"name":"Department ofDermatology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-5707","authenticated-orcid":false,"given":"Toshihisa","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department ofDermatology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Tsuchiya","sequence":"additional","affiliation":[{"name":"Department ofChild Neurology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department ofChild Neurology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyasu","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department ofDermatology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"},{"name":"Department of Dermatology Kagoshima University Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiro","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department ofChild Neurology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Iwatsuki","sequence":"additional","affiliation":[{"name":"Department ofDermatology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-39"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0540-2"},{"key":"e_1_2_5_4_1","first-page":"319","volume-title":"Dermatology","author":"French 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