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A comparison of neutrophil gelatinase\u2010associated lipocalin levels on the cheeks of patients with acne vulgaris at the start of the study and at the time of symptom improvement showed a significant decrease. On the other hand, the galectin\u20107 levels at the time of symptom improvement were significantly higher than those at the start of the study. Therefore, because the inflammation in the epidermis and hair follicles was reduced after therapy, as a result of the solution of the inflammatory eruptions caused by acne vulgaris, the neutrophil gelatinase\u2010associated lipocalin level also showed a significant decrease after therapy. These results suggest that stratum corneum neutrophil gelatinase\u2010associated lipocalin may be useful as an objective biomarker of changes in acne vulgaris symptoms.<\/jats:p>","DOI":"10.1111\/1346-8138.14261","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T06:22:48Z","timestamp":1519366968000},"page":"618-621","source":"Crossref","is-referenced-by-count":3,"title":["Clinical significance of neutrophil gelatinase\u2010associated lipocalin and galectin\u20107 in tape\u2010stripped stratum corneum of acne vulgaris"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-6981","authenticated-orcid":false,"given":"Kosuke","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Dermatology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Fancl Research Institute Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misaki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Kondo","sequence":"additional","affiliation":[{"name":"Fancl Research Institute Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minako","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Fancl Research Institute Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoko","family":"Matsukuma","sequence":"additional","affiliation":[{"name":"Fancl Research Institute Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetsugu","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Toho University Ohashi Medical Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/9781616310097-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.3.799.799"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106089200"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2002.110611.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700035"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5458-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1995.1078"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.1998.6330159.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12326"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1346-8138.2007.00403.x-i1","article-title":"Acne Study Group. 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