{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:29:13Z","timestamp":1790357353102,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is currently a growing interest in new diagnostic tools of the oral cavity and mucosa which are non\u2010invasive, repeatable and reliable. A diagnosis of a suspected, autoimmune pathology was made regarding a 57\u2010year\u2010old patient with desquamative gingivitis. However, a negative Nikolsky's sign did not seem to indicate a diagnosis of mucous membrane pemphigoid neither was there any indication as to the optimum location for an incisional biopsy. As an imaging method, the use of optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) has enabled the obtaining of tomographic (cross\u2010sectional) scans of tissue. Such images are acquired prior to and after verifying Nikolsky's sign, thereby enabling the clinician to identify the presence (or not) of subepithelial bullae. Thereafter, an assessment of changes in the subepithelium (the split) can be performed, even in the absence of a suitable clinical picture, such as, for example, a negative Nikolsky's sign. Histological analysis and the use of indirect immunofluorescence have facilitated a diagnosis of mucous membrane pemphigoid, an autoimmune pathology, which can be confirmed with the appearance of subepithelial bullae. <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> was found to be a valid, non\u2010invasive, auxiliary diagnostic device, capable of revealing <jats:italic>in vivo<\/jats:italic> and real\u2010time bullae, which were hitherto clinically undetectable.<\/jats:p>","DOI":"10.1111\/1346-8138.14267","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T07:12:43Z","timestamp":1519629163000},"page":"603-605","source":"Crossref","is-referenced-by-count":13,"title":["<i>In vivo<\/i> optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8578-8041","authenticated-orcid":false,"given":"Giorgia","family":"Capocasale","sequence":"first","affiliation":[{"name":"Department of Surgical, Oncological and Oral Sciences University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Panzarella","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Oral Sciences University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Rodolico","sequence":"additional","affiliation":[{"name":"Human Pathology Department of Health Promotion and Mother and Child Care University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Di Fede","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Oral Sciences University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Campisi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Oncological and Oral Sciences University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.200"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12639"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04142.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00033.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080217"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13314"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2003.139"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2009.04.019"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-4-29"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2012.07.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02917.x"},{"issue":"3","key":"e_1_2_6_13_1","first-page":"39","article-title":"In vivo characterization of oral pemphigus vulgaris by Optical Coherence Tomography","volume":"29","author":"Di Stasio D","year":"2015","journal-title":"J Biol Regul Homeost Agents"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14267","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:17:14Z","timestamp":1695557834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,26]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/1346-8138.14267"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14267","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,26]]}}}