{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:35:07Z","timestamp":1771457707300,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T00:00:00Z","timestamp":1520035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Stress\u2010induced scratching is an issue in patients with adult atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>). Symptoms of stress\u2010induced <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> are common in clinical practise. Salivary chromogranin A (CgA) level has research value as a possible index related to a patient's psychological stress. Using saliva, which is easily collectable, we compared two assessments of the severities of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and stress with the levels of stress proteins in the saliva of 30 patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in the Department of Dermatology of Shimane University between April 2015 and May 2017. The severities of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and stress were assessed using the Scoring Atopic Dermatitis (<jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content>) score and State\u2013Trait Anxiety Inventory score, respectively. Additionally, the assessments included those of personality using the Tokyo University Egogram (<jats:styled-content style=\"fixed-case\">TEG<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> score and quality of life using the Dermatology Life Quality Index score. Simultaneously, we measured their salivary CgA levels. The change in salivary CgA per protein in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> was correlated with their changes in <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content> score (correlation coefficient, <jats:italic>r<\/jats:italic> = 0.596, <jats:italic>P<\/jats:italic> = 0.001) and objective <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = 0.608, <jats:italic>P<\/jats:italic> &lt; 0.001). The changes in CgA per protein correlated with those in <jats:styled-content style=\"fixed-case\">TEG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> A (<jats:italic>r<\/jats:italic> = 0.370, <jats:italic>P<\/jats:italic> = 0.022), while the changes in <jats:styled-content style=\"fixed-case\">SCORAD<\/jats:styled-content> score correlated with those in <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> (<jats:italic>r<\/jats:italic> = 0.309, <jats:italic>P<\/jats:italic> = 0.048). Our results suggest that changes in a patient's condition are reflective of the changes in the patient's stress. The changes in salivary CgA level in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> correlated with the changes in their condition.<\/jats:p>","DOI":"10.1111\/1346-8138.14277","type":"journal-article","created":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T06:26:38Z","timestamp":1520058398000},"page":"554-559","source":"Crossref","is-referenced-by-count":8,"title":["Changes in salivary chromogranin A levels in adults with atopic dermatitis are correlated with changes in their condition"],"prefix":"10.1111","volume":"45","author":[{"given":"Liang","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Shimane University Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-8505","authenticated-orcid":false,"given":"Sakae","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Shimane University Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eishin","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Shimane University Izumo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.2.125"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8231-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7541.584"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2005.03.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0158"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.043"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0579.2007.00477.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.28.57"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/1463-1741.33951"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.54.140"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13852"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-10-854"},{"key":"e_1_2_7_14_1","first-page":"283","volume-title":"Psychoneuroimmunology","author":"Madden KS","year":"1992"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70130-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14883"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3345"},{"key":"e_1_2_7_18_1","first-page":"806","article-title":"Assessment of depression and anxiety in outpatient atopic dermatitis (AD) patients and salivary stress markers","volume":"118","author":"Yamakita T","year":"2008","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_7_19_1","first-page":"4","volume-title":"Tokyo University Egogram New Version II","author":"Tokyo University Faculty of Medicine Department of Psychosomatic Medicine TEG Study Group","year":"2013"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.19.401"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8760(02)00067-3"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:15:29Z","timestamp":1695557729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,3]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/1346-8138.14277"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14277","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,3]]}}}