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We report a case of drug adverse reaction that does not fulfill the diagnostic criteria of DIHS but mimics its characteristic features. Because the patient was under anti\u2010IL\u20106 therapy at the onset, some symptoms typically seen in DIHS were absent, such as fever and leukocyte count abnormalities. However, the characteristic features of DIHS were clearly observed in the subsequent course, including the repeated recurrence of skin rash, prolonged liver dysfunction and reactivation of herpes viruses. This case suggested that IL\u20106 role at the onset is not a main factor to determine the subsequent pathomechanism of DIHS and attention should be paid to the preceding therapy for achieving accurate diagnosis.<\/jats:p>","DOI":"10.1111\/1346-8138.14288","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T04:53:46Z","timestamp":1521780826000},"page":"738-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Case of lamotrigine\u2010induced drug adverse reaction under tocilizumab treatment with clinical and virological features of drug\u2010induced hypersensitivity syndrome"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4022-8950","authenticated-orcid":false,"given":"Hisato","family":"Iriki","sequence":"first","affiliation":[{"name":"Department of Dermatology Keio University School of Medicine Tokyo 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