{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:39:48Z","timestamp":1787013588853,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T00:00:00Z","timestamp":1523664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Biologics show great efficacy in treating psoriasis, a chronic inflammatory skin disease. The high cost and side\u2010effects of biologics, dose\u2010reduction, elongation of administration interval and suspension are possible options. However, there has been no reliable biomarker we can use when we consider these moderations in therapy. This study was conducted to test the possibility of using serum thymus and activation\u2010regulated chemokine (\n                    <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>\n                    ) level as an indicator for step down of biologic therapy. Serum\n                    <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>\n                    level was measured in 70 psoriatic patients at Asahikawa Medical University, and a correlation of\n                    <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>\n                    and severity of skin lesions was analyzed. Referring to serum\n                    <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>\n                    level, psoriatic patients can be divided into two groups. One is a population in which serum\n                    <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>\n                    level is positively correlated with severity of skin lesions, and the other is a population with low psoriatic severity and high\n                    <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>\n                    level. Serum\n                    <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>\n                    level was higher in the group that achieved\n                    <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>\n                    \u2010clear with biologics than in the group which did not achieve\n                    <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>\n                    \u2010clear. Among biologics, the group treated with secukinumab, an anti\u2010interleukin (\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    )\u201017A agent, showed significantly higher\n                    <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>\n                    level compared with the group treated with anti\u2010tumor necrosis factor agents. In certain populations achieving\n                    <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>\n                    \u2010clear, serum\n                    <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>\n                    level may be a potent marker reflecting better response to\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201017A inhibitors, and in this case step down of treatment for psoriasis is possible.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.14308","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T19:00:07Z","timestamp":1523732407000},"page":"710-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Alteration of serum thymus and activation\u2010regulated chemokine level during biologic therapy for psoriasis: Possibility as a marker reflecting favorable response to anti\u2010interleukin\u201017A agents"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3913-6880","authenticated-orcid":false,"given":"Takashi","family":"Shibuya","sequence":"first","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1566-5331","authenticated-orcid":false,"given":"Masaru","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3673-0932","authenticated-orcid":false,"given":"Shin","family":"Iinuma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa 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