{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:38:14Z","timestamp":1790811494320,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T00:00:00Z","timestamp":1524787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content>) is the second most common skin cancer and its incidence is rising. The prognosis is mostly good but patients with high\u2010risk <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> have a greater risk of recurrence and death. The aim of the present study was to conduct a systematic review analyzing the prevalence, predictors and prognostic utility of sentinel lymph node (<jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content>) involvement in <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content>. We performed a published work search in Ovid <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> and reviewed the reference lists of selected studies. Based on the 23 studies included in the systematic review, the proportion of patients with <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> and positive <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> biopsy findings was 8% (95% confidence interval, 5.1\u201310.8%; <jats:italic>I<\/jats:italic><jats:sup><jats:italic>2<\/jats:italic><\/jats:sup>= 44.51%). We found no studies reporting on predictors of <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> involvement in <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> or on the prognostic utility of this finding following adjustment for confounders. The rate of positive <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> is less than previously reported. Criteria for recommending <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> biopsy as a staging tool for <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content> vary considerably from study to study, and none of the studies were large enough to reliably identify predictors of <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> positivity. No randomized controlled trials have yet analyzed whether <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> biopsy may improve the prognosis of <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content>. More studies are required on the prognostic value of <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> positivity and the associated risk factors in <jats:styled-content style=\"fixed-case\">cSCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.14342","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T10:48:32Z","timestamp":1524826112000},"page":"781-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Systematic review of the prevalence of nodal metastases and the prognostic utility of sentinel lymph node biopsy in cutaneous squamous cell carcinoma"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-0744","authenticated-orcid":false,"given":"Antonio","family":"Tejera\u2010Vaquerizo","sequence":"first","affiliation":[{"name":"Dermatology Department Instituto Dermatol\u00f3gico GlobalDerm Palma del 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