{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:38:21Z","timestamp":1779233901050,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T00:00:00Z","timestamp":1525305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002468","name":"Dong-A University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002468","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne vulgaris is one of the most common dermatological problems, and its therapeutic options include topical and systemic retinoids and antibiotics. However, increase in problems associated with acne treatment, such as side\u2010effects from conventional agents and bacterial resistance to antibiotics, has led to greater use of photodynamic therapy. The purpose of this study was to compare the bactericidal effects of indocyanine green\u2010 and methyl aminolevulinate\u2010based photodynamic therapy on <jats:italic>Propionibacterium acnes<\/jats:italic>. <jats:italic>P.\u00a0acnes<\/jats:italic> were cultured under anaerobic conditions; then they were divided into three groups (control, treated with indocyanine green and treated with methyl aminolevulinate) and illuminated with different lights (630\u2010nm light\u2010emitting diode, 805\u2010nm diode laser and 830\u2010nm light\u2010emitting diode). The bactericidal effects were evaluated by comparing each group's colony\u2010forming units. The cultured <jats:italic>P.\u00a0acnes<\/jats:italic> were killed with an 805\u2010nm diode laser and 830\u2010nm light\u2010emitting diode in the indocyanine green group. No bactericidal effects of methyl aminolevulinate\u2010based photodynamic therapy were identified. The clinical efficacy of indocyanine green\u2010based photodynamic therapy in 21 patients was retrospectively analyzed. The Korean Acne Grading System was used to evaluate treatment efficacy, which was significantly decreased after treatment. The difference in the efficacy of the 805\u2010nm diode laser and 830\u2010nm light\u2010emitting diode was not statistically significant. Although the methyl aminolevulinate\u2010based photodynamic therapy showed no bactericidal effect, the indocyanine green\u2010based photodynamic therapy has bactericidal effect and clinical efficacy.<\/jats:p>","DOI":"10.1111\/1346-8138.14347","type":"journal-article","created":{"date-parts":[[2018,5,3]],"date-time":"2018-05-03T10:49:25Z","timestamp":1525344565000},"page":"824-829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Comparative study of the bactericidal effects of indocyanine green\u2010 and methyl aminolevulinate\u2010based photodynamic therapy on <i>Propionibacterium acnes<\/i> as a new treatment for acne"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5353-0334","authenticated-orcid":false,"given":"Seung\u2010Hwan","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine Dong\u2010A University Busan 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