{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:29:44Z","timestamp":1780921784675,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,6]],"date-time":"2018-05-06T00:00:00Z","timestamp":1525564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports, Culture and Technology of Japan","doi-asserted-by":"crossref","award":["19791180"],"award-info":[{"award-number":["19791180"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pustulosis palmaris et plantaris (<jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content>) and pustulotic arthro\u2010osteitis (<jats:styled-content style=\"fixed-case\">PAO<\/jats:styled-content>) are tonsil\u2010related diseases. Treatment outcome of tonsillectomy and prognostic factors influencing the outcome have not been analyzed quantitatively. We evaluated those using the Palmoplantar Pustulosis Area and Severity Index (<jats:styled-content style=\"fixed-case\">PPPASI<\/jats:styled-content>). At 1, 3, 6, 12, 24 and more than 24 months post\u2010tonsillectomy, 20 (31%), 34 (48%), 70 (60%), 57 (80%), 36 (95%) and 23 (96%) patients realized 80% or more improvement of <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content> skin lesions, respectively, and eight (17%), 23 (36%), 30 (50%), 38 (79%), 12 (100%) and four (100%) patients showed 80% or more improvement of <jats:styled-content style=\"fixed-case\">PPPASI<\/jats:styled-content> (i.e. <jats:styled-content style=\"fixed-case\">PPPASI<\/jats:styled-content>% \u2265 80%), respectively. At 1, 3, 6, 12 and more than 12 months post\u2010tonsillectomy, 19 (73%), 21 (66%), 27 (73%), 19 (79%) and 15 (83%) patients realized a disappearance of <jats:styled-content style=\"fixed-case\">PAO<\/jats:styled-content>\u2010induced arthralgia, respectively. Kaplan\u2013Meier analysis of 80 patients with <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content> revealed that, at 12 and 24 months post\u2010tonsillectomy, lesions disappeared (i.e. <jats:styled-content style=\"fixed-case\">PPPASI<\/jats:styled-content> = 0) in 38% and 66% of patients, respectively, and lesions improved by 80% or more (i.e. <jats:styled-content style=\"fixed-case\">PPPASI<\/jats:styled-content>% \u2265 80%) in 71% and 95% of patients, respectively. The log\u2013rank test and univariate and multivariate analyses showed that smoking cessation post\u2010tonsillectomy and <jats:styled-content style=\"fixed-case\">PAO<\/jats:styled-content> were significant predictive factors for the early disappearance of skin lesions. This report is the first demonstrating objective evidence of the great efficacy of tonsillectomy to improve <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content> skin lesions. Even post\u2010tonsillectomy, smoking inhibited the early disappearance of the lesions.<\/jats:p>","DOI":"10.1111\/1346-8138.14348","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T06:29:46Z","timestamp":1525674586000},"page":"812-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Treatment outcome and prognostic factors of tonsillectomy for palmoplantar pustulosis and pustulotic arthro\u2010osteitis: A retrospective subjective and objective quantitative analysis of 138 patients"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0535-5778","authenticated-orcid":false,"given":"Miki","family":"Takahara","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Nagato","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Kishibe","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Katada","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Kishibe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3104-102X","authenticated-orcid":false,"given":"Akemi","family":"Ishida\u2010Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuaki","family":"Harabuchi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12094.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2340\/0001555551284288","article-title":"Pustulosis palmaris et plantaris. 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