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A retrospective investigation was conducted with three children afflicted with a severe hyperkeratotic disorder, namely Darier's disease, bullous ichthyosiform erythroderma or lamellar ichthyosis, who were continuously maintained on 0.2\u20130.3 mg\/kg per day acitretin for more than 12 years after an initial period at a larger acitretin dose to bring each disease under control. The patients had good responses to acitretin treatment, which was assessed for safety, skeletal abnormalities, growth retardation and other potential side\u2010effects. Acitretin monotherapy was an effective treatment for these children, and maintenance doses were well tolerated with no skeletal or other observable side\u2010effects during the course of the study.<\/jats:p>","DOI":"10.1111\/1346-8138.14462","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T07:16:13Z","timestamp":1526282173000},"page":"1003-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Long\u2010term safety and efficacy of continuous acitretin monotherapy for three children with different severe hyperkeratotic disorders in China"],"prefix":"10.1111","volume":"45","author":[{"given":"Jingyao","family":"Liang","sequence":"first","affiliation":[{"name":"Institute of Dermatology Guangzhou Medical University Guangzhou China"},{"name":"Department of Dermatology Guangzhou Institute of Dermatology Guangzhou 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