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Reports on the clinical efficacy of <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> in patients with skin lesions have appeared in the published work. Dermatological diseases, which are known to respond to <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content>, include pyoderma gangrenosum, skin lesions of Beh\u00e7et's disease, rheumatoid arthritis, pustular psoriasis, psoriatic arthritis, adult\u2010onset Still's disease, Sweet's syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus rashes. In association with clinical studies, efforts to understand the mechanisms of <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> have made significant progress. <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> selectively depletes elevated myeloid lineage leukocytes through binding between blood immunoglobulin G or complement <jats:styled-content style=\"fixed-case\">iC<\/jats:styled-content>3b, which form on the surface of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> beads and the Fc\u03b3 receptors or complement receptors expressed on the myeloid lineage cells. However, <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> has immunomodulatory effects including down\u2010modulation of inflammatory cytokine profile, changes in leukocyte surface receptors and induction of regulatory T cells. These actions render <jats:styled-content style=\"fixed-case\">GMA<\/jats:styled-content> a unique non\u2010pharmacological treatment option for patients with chronic dermatoid conditions, which are difficult to treat with pharmacological preparations.<\/jats:p>","DOI":"10.1111\/1346-8138.14471","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T15:36:00Z","timestamp":1526916960000},"page":"943-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical and immunological effects of adsorptive myeloid lineage leukocyte apheresis in patients with immune disorders"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3904-5954","authenticated-orcid":false,"given":"Takuro","family":"Kanekura","sequence":"first","affiliation":[{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima 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