{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:33:54Z","timestamp":1789475634119,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nuclear factor (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>)\u2010\u03baB essential modifier (<jats:italic><jats:styled-content style=\"fixed-case\">NEMO<\/jats:styled-content><\/jats:italic>), also known as I\u03baB kinase subunit\u2010\u03b3 (<jats:styled-content style=\"fixed-case\">IKK<\/jats:styled-content>\u03b3), is a pivotal molecule in the <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB signaling pathway. Mutations of <jats:italic><jats:styled-content style=\"fixed-case\">NEMO<\/jats:styled-content><\/jats:italic> cause incontinentia pigmenti and X\u2010linked ectodermal dysplasia with immunodeficiency. Mendelian susceptibility to mycobacterial diseases (<jats:styled-content style=\"fixed-case\">MSMD<\/jats:styled-content>), which confers an almost selective predisposition to mycobacterial infection, is also caused by <jats:italic><jats:styled-content style=\"fixed-case\">NEMO<\/jats:styled-content><\/jats:italic> mutations. We herein report the first case of a patient with X\u2010linked recessive (<jats:styled-content style=\"fixed-case\">XR<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">MSMD<\/jats:styled-content> who developed cutaneous squamous cell carcinoma, thyroid cancer and Langerhans cell histiocytosis. The relationship between <jats:italic><jats:styled-content style=\"fixed-case\">NEMO<\/jats:styled-content><\/jats:italic> mutation and oncogenesis is discussed.<\/jats:p>","DOI":"10.1111\/1346-8138.14482","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T10:05:25Z","timestamp":1527156325000},"page":"1017-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cutaneous squamous cell carcinoma, thyroid cancer and Langerhans cell histiocytosis in a patient with X\u2010linked recessive Mendelian susceptibility to mycobacterial diseases with a nuclear factor\u2010\u03baB essential modifier mutation"],"prefix":"10.1111","volume":"45","author":[{"given":"Yuta","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi 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