{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:52:09Z","timestamp":1772772729596,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009564","name":"Health and Family Planning Commission of Sichuan Province","doi-asserted-by":"publisher","award":["17PJ148"],"award-info":[{"award-number":["17PJ148"]}],"id":[{"id":"10.13039\/501100009564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>Elevated serum procalcitonin (PCT<\/jats:styled-content>) level has been reported to be a diagnostic index in systemic bacterial infections, but it can also increase in some non\u2010infectious inflammatory diseases. Stevens\u2013Johnson syndrome (SJS<\/jats:styled-content>)\/toxic epidermal necrolysis (TEN<\/jats:styled-content>) is a rare immune\u2010mediated cutaneous mucosal reaction which is susceptible to bacterial infections and may have elevated PCT<\/jats:styled-content> levels. The value of serum PCT<\/jats:styled-content> has not been assessed in series of SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> patients. We aimed to investigate the PCT<\/jats:styled-content> levels in SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> patients with systemic bacterial infections (systemic infected group), with skin surface bacterial infections (skin surface infected group) and without infections (non\u2010infected group), to assess whether PCT<\/jats:styled-content> was a valuable indicator for systemic bacterial infections in SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> patients. The PCT<\/jats:styled-content> and C\u2010reactive protein (CRP<\/jats:styled-content>) levels of 42 inpatients with SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> were retrospectively analysis. The receiver\u2013operator curve (ROC<\/jats:styled-content>) was used to determine the diagnostic efficacy of PCT<\/jats:styled-content> for systemic bacterial infections in SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> patients. The results demonstrated that PCT<\/jats:styled-content> levels in the systemic infected group were significantly higher than those in the other two groups (P<\/jats:italic> < 0.05). There was no significant difference in CRP<\/jats:styled-content> between the three groups. The cut\u2010off PCT<\/jats:styled-content> level of 0.65 ng\/mL calculated by ROC<\/jats:styled-content> had optimal diagnostic efficacy, with sensitivity and specificity of 84.6% and 89.7%, respectively. PCT<\/jats:styled-content> and severity\u2010of\u2010illness score for toxic epidermal necrolysis were positively correlated (P<\/jats:italic> < 0.05). In conclusion, PCT<\/jats:styled-content> is a valuable index and superior to CRP<\/jats:styled-content> in detecting systemic bacterial infections in SJS<\/jats:styled-content>\/TEN<\/jats:styled-content> patients. The level of PCT<\/jats:styled-content> can partially reflect the severity of the disease.<\/jats:p>","DOI":"10.1111\/1346-8138.14488","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T09:25:16Z","timestamp":1528881916000},"page":"989-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Procalcitonin as a diagnostic indicator for systemic bacterial infections in patients with Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis"],"prefix":"10.1111","volume":"45","author":[{"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Dermatology and Venereology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Bing","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine North Sichuan Medical 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