{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:45:37Z","timestamp":1789969537052,"version":"4.0.1"},"reference-count":9,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lupus erythematosus profundus (<jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content>) is a variant of lupus erythematosus, involving the deep dermis and subcutaneous fat. <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> is characterized by the presence of lymphoid follicles (<jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>) and germinal centers (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>). However, it remains unknown whether these lymphoid structures correspond to the lymphoid tissues such as cutaneous tertiary lymphoid organs (<jats:styled-content style=\"fixed-case\">TLO<\/jats:styled-content>). Previously, we identified dynamically orchestrated cellular elements in murine contact dermatitis that resembled lymphoid structures, which we termed inducible skin\u2010associated lymphoid tissues (<jats:styled-content style=\"fixed-case\">iSALT<\/jats:styled-content>). We subsequently reported structures analogous to <jats:styled-content style=\"fixed-case\">iSALT<\/jats:styled-content> in human secondary syphilis, suggesting that <jats:styled-content style=\"fixed-case\">iSALT<\/jats:styled-content> can also exist in humans. Here, we studied ectopic lymphoid tissues in the lesions of <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> by immunohistochemistry and compared their characteristics with those of <jats:styled-content style=\"fixed-case\">TLO<\/jats:styled-content>. We demonstrated that <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> were composed of B\u2010cell follicles intermingled with <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>13\u2010expressing cells, distinct aggregations of T cells, and some blood vessels expressing peripheral node addressin. These findings indicate that <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">LEP<\/jats:styled-content> can be considered as a type of <jats:styled-content style=\"fixed-case\">iSALT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.14498","type":"journal-article","created":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T09:31:50Z","timestamp":1528882310000},"page":"1117-1121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Analysis of possible structures of inducible skin\u2010associated lymphoid tissue in lupus erythematosus profundus"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-719X","authenticated-orcid":false,"given":"Toshiaki","family":"Kogame","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Ijinkai Takeda General Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki R.","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Kamido","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyuki","family":"Ueshima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kyoto University Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Matsui","sequence":"additional","affiliation":[{"name":"Ijinkai Takeda General Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70389-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2005.00351.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001700316"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12547071"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2992"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15349"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.11.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu019"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0911-z"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:00:52Z","timestamp":1695016852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/1346-8138.14498"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14498","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,13]]},"assertion":[{"value":"2018-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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