{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:20:46Z","timestamp":1779236446947,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are inconsistent data on mortality rates in patients with bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>). Trends in mortality in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> throughout the years are yet to be established. The aim of the present study was to study the mortality in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients relative to the general population and to estimate trends in standardized mortality over the past 30\u00a0years. We performed a systematic review and meta\u2010analysis of observational studies in Medline, Embase and Scopus (1823\u20132017). Reference lists of included studies were also searched for eligible studies. Quality of evidence was assessed using the Newcastle\u2013Ottawa Scale (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>). A meta\u2010analysis was performed using random\u2010effects models to estimate pooled standardized mortality ratios (<jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>) with 95% confidence intervals (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>). Meta\u2010regression models were used to investigate the secular trends in <jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>. Ten studies were included covering the period 1960\u20132015 (1736 patients, 746 deaths). Pooled all\u2010cause <jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content> was 3.6 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 2.6\u20135.0). There was no trend in all\u2010cause <jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content> across the last three decades (regression coefficient 0.02 [change in log<jats:styled-content style=\"fixed-case\">SMR<\/jats:styled-content>\/year]; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.04\u20130.08; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.545). In conclusion, there is a 3.6\u2010fold increased mortality among patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> as compared with the age\u2010matched general population. The excess mortality in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> has not changed significantly over the past 30\u00a0years.<\/jats:p>","DOI":"10.1111\/1346-8138.14503","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T10:04:33Z","timestamp":1529057073000},"page":"1094-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Mortality in bullous pemphigoid: A systematic review and meta\u2010analysis of standardized mortality ratios"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-9151","authenticated-orcid":false,"given":"Khalaf","family":"Kridin","sequence":"first","affiliation":[{"name":"Department of Dermatology Rambam Health Care Campus Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naama","family":"Schwartz","sequence":"additional","affiliation":[{"name":"School of Public Health University of Haifa Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Quality Measurements and Research Chief Physician's Office Clalit Health Services Tel Aviv Israel"},{"name":"Siaal Research Center for Family Medicine and Primary Care Faculty of Health Sciences Ben\u2010Gurion University of the Negev Beer\u2010Sheeva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shira","family":"Zelber\u2010Sagi","sequence":"additional","affiliation":[{"name":"School of Public Health University of Haifa Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1531-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.35"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06976_supp.x"},{"issue":"7662","key":"e_1_2_7_5_1","first-page":"160","article-title":"Bullous pemphigoid and pemphigus vulgaris \u2010 Incidence and mortality in the UK: population based cohort study","volume":"337","author":"Langan SM","year":"2008","journal-title":"BMJ"},{"issue":"8","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1001\/archderm.1977.01640080045002","article-title":"Bullous pemphigoid: clinical and immunologic follow\u2010up after successful therapy","volume":"113","author":"Ahmed AR","year":"1977","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.4.465"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.022"},{"issue":"6","key":"e_1_2_7_9_1","first-page":"758","article-title":"Risk of death in bullous pemphigoid: a retrospective database study in Finland","volume":"96","author":"F\u00f6rsti AK","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.02.030"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-010-9491-z"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.05.006"},{"issue":"11","key":"e_1_2_7_13_1","first-page":"751","article-title":"Survival prognosis in pemphigoid. 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