{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:46:49Z","timestamp":1783075609742,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T00:00:00Z","timestamp":1529020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Granuloma faciale (<jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content>) is a rare chronic dermatosis with still unknown etiopathology, which usually presents a solitary, asymptomatic, smooth reddish\u2010brown to violaceous plaques or nodules on the face. Various therapeutic approaches, including topical application of corticosteroid or tacrolimus and removal with laser, cryotherapy and surgery have been attempted; however, the outcome has been inconsistent. Herein, we report a case of perinasal nodular <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> who repeatedly underwent surgical excisions after the failure of laser treatment. Despite its nomenclature, <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> does not manifest granulomatous tissue and the lesion is histopathologically characterized by dense dermal cell infiltration devoid of granulomatous changes and not distinguished by a clear border, which partially explains the difficulty of complete removal in our case. Review of the published work delineated that <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> could be largely divided into two clinical subsets: plaque and nodular types. The plaque type <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> could be responsive to topical tacrolimus, an approach preferentially adopted nowadays, while nodular type <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> was often resistant to topical therapies and required surgical or laser removal. The latter subset often arose around the nose. For this location, surgical excision with sufficient removal margin is sometimes technically difficult when an aesthetically acceptable outcome is expected, explaining the basis for local recurrence. Postoperative recurrence could be observed after years of disease\u2010free period. These observations indicated that the need for respective treatment strategies for the management of distinctive <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> subsets. Of note, a multidisciplinary approach combining radical resection and additional supportive intervention with long\u2010term follow up may be required for perinasal and nodular <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.14507","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T10:14:51Z","timestamp":1529057691000},"page":"1122-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chronological observation of surgically\u2010treated granuloma faciale implies the necessity of circumspect management for perinasal nodular subset"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7875-8124","authenticated-orcid":false,"given":"Yurie","family":"Shimoda\u2010Komatsu","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyorin University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-6663","authenticated-orcid":false,"given":"Misaki","family":"Kinoshita\u2010Ise","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyorin University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimoyamada","sequence":"additional","affiliation":[{"name":"Department of Pathology Kyorin University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-5717","authenticated-orcid":false,"given":"Manabu","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyorin University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2784"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05550.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.021"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2009.00543.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243806"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12365"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.37.4.215"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1985.tb02885.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870070097018"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01555.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12649"},{"key":"e_1_2_5_13_1","first-page":"306","article-title":"Granuloma faciale","volume":"99","author":"Khaled A","year":"2007","journal-title":"Pathologica"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.105464"},{"key":"e_1_2_5_15_1","first-page":"125","article-title":"Eosinophilic granuloma? Sarcoid of Boeck","volume":"38","author":"Weigley JE","year":"1945","journal-title":"Proc R Soc Med"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13176"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:00:41Z","timestamp":1695016841000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,15]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/1346-8138.14507"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14507","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,15]]},"assertion":[{"value":"2018-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}