{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:16:14Z","timestamp":1790507774749,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin (IL)\u201034 is a hematopoietic cytokine promoting proliferation and differentiation of macrophages. Because abnormal activation of macrophages is involved in the development of systemic sclerosis (SSc), we investigated serum IL\u201034 levels in patients with SSc. Serum IL\u201034 levels were significantly increased in diffuse cutaneous SSc compared with limited cutaneous SSc and healthy controls, while there were no significant differences between limited cutaneous SSc and healthy controls. In addition, SSc patients with increased serum IL\u201034 levels more often had interstitial lung disease (ILD) than those with normal levels. Moreover, in SSc patients, serum IL\u201034 levels negatively correlated with the percentage of predicted vital capacity, while they positively correlated with ground\u2010glass opacity score and fibrotic score on chest computed tomography. Collectively, increased serum IL\u201034 levels were associated with greater frequency and severity of ILD in SSc patients. Serum IL\u201034 levels may be a useful serological marker for SSc\u2010associated ILD.<\/jats:p>","DOI":"10.1111\/1346-8138.14538","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T14:44:54Z","timestamp":1531493094000},"page":"1216-1220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Serum interleukin\u201034 levels in patients with systemic sclerosis: Clinical association with interstitial lung disease"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-7469","authenticated-orcid":false,"given":"Ai","family":"Kuzumi","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Yoshizaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate 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