{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:37:30Z","timestamp":1790422650372,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systemic sclerosis (SSc) is an autoimmune disorder characterized by excessive extracellular matrix deposition. Although SSc\u2010associated interstitial lung disease (ILD) is one of the most important complications as a cause of death in SSc, prediction factors of treatment reactivity in SSc\u2010ILD are still unclear. To assess relationships between interleukin (IL)\u20106 and reactivity to treatment, we measured serum IL\u20106 levels in 23 of active SSc\u2010ILD patients under i.v. cyclophosphamide (IVCY) therapy and 20 of stabilized SSc\u2010ILD, using the high\u2010sensitivity enzyme\u2010linked immunoassay system. Serum IL\u20106 levels in active SSc\u2010ILD patients were significantly higher than those in stabilized SSc\u2010ILD patients. Among active SSc\u2010ILD patients, baseline serum IL\u20106 levels were not significantly different between IVCY responders and non\u2010responders. Meanwhile, serum IL\u20106 levels after three IVCY doses out of a total of six were decreased in responders but not in non\u2010responders. Regarding changes of parameters by the three doses of a total of six of IVCY, change in serum IL\u20106 levels correlated inversely with that in values of pulmonary function test. Thus, the rapid decrease in serum IL\u20106 levels during a couple of doses may predict the efficacy of IVCY therapy against SSc\u2010ILD.<\/jats:p>","DOI":"10.1111\/1346-8138.14580","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T10:04:27Z","timestamp":1532685867000},"page":"1221-1224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Rapid alteration of serum interleukin\u20106 levels may predict the reactivity of i.v. cyclophosphamide pulse therapy in systemic sclerosis\u2010associated interstitial lung disease"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1998-3126","authenticated-orcid":false,"given":"Hiroko","family":"Numajiri","sequence":"first","affiliation":[{"name":"Department of Dermatology Graduate School of Medicine The University of Tokyo Tokyo 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