{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:48Z","timestamp":1791895608253,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Acne vulgaris is a chronic inflammatory dermatosis affecting approximately 85% of adolescents. There are many factors contributing to the development of this ailment. A recent study indicated that gut microbiota takes part in the pathogenesis of acne. We aimed to investigate the link between acne vulgaris and gut microbiota. A total of 31 moderate to severe acne vulgaris patients and 31 healthy controls were enrolled. We collected their feces, and gut microbiota was evaluated by the hypervariable regions of 16S\n                    <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content>\n                    genes through high\u2010throughput sequencing. We identified links between acne vulgaris and changes of gut microbiota. At the phylum level, Actinobacteria (0.89% in acne patients and 2.84% in normal controls,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.004) was decreased and Proteobacteria (8.35% in acne patients and 7.01% in normal controls,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.031) was increased. At the genus level,\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Butyricicoccus<\/jats:italic>\n                    ,\n                    <jats:italic>Coprobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Allobaculum<\/jats:italic>\n                    were all decreased. The observed difference in genera between acne patients and healthy controls provides a new insight into the link between gut microbiota changes and acne vulgaris risk.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.14586","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T06:15:13Z","timestamp":1534140913000},"page":"1166-1171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Gut microbiota alterations in moderate to severe acne vulgaris patients"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2167-7964","authenticated-orcid":false,"given":"Hui\u2010Min","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital Beijing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University Third Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12149"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Pathogenesis of acne: recent research advances","volume":"19","author":"Harper JC","year":"2003","journal-title":"Adv Dermatol"},{"key":"e_1_2_7_4_1","first-page":"39","article-title":"Impact of the impaired intestinal microflora on the course of acne vulgaris","volume":"6","author":"Volkova LA","year":"2001","journal-title":"Klin Med 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