{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:08:24Z","timestamp":1791558504744,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T00:00:00Z","timestamp":1536105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science & Technology Action Plans for the Prevention and Treatment of Major Diseases","award":["2017ZX-01E-002"],"award-info":[{"award-number":["2017ZX-01E-002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The skin microbiota is an inseparable component of the skin barrier structure, which participates in the stabilization or impairment of the barrier function as well as the development of many skin diseases. To characterize the normal skin microbiota and its association with skin sites, age and sex, we recruited 50 volunteers divided into children, adolescents, young adults, middle\u2010aged adults and the elderly. The skin sites consisted of cheeks, volar forearms (representing dry environments) and upper back (representing sebaceous environments). A total of 9 574 365 high\u2010quality sequences of the V3 to V4 region of the 16\n                    <jats:italic>S<\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content>\n                    gene were annotated with taxonomic information related to two archaeal phyla (Thaumarchaeota and Euryarchaeota) and five dominant bacterial phyla (Actinobacteria, Proteobacteria, Firmicutes, Bacteroidetes and Cyanobacteria). The skin bacteria community structure was influenced by skin sites, and was closely related to age and sex. The upper back was dominated by\n                    <jats:italic>Propionibacterium<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    , and the cheeks facilitated the survival of Betaproteobacteria, while Alphaproteobacteria were prevalent on the volar forearms. Regarding the effects of age, after sexual maturity, the cheek microbiota became more similar to sebaceous sites (i.e. the upper back). The volar forearms appeared to experience the aging process earlier than the other two sites. The elderly had greater species richness and diversity and their community composition no longer had skin\u2010site selectivity. Males had a greater species richness than females, but the sex differences in the community structure only present at certain age groups and skin sites.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.14594","type":"journal-article","created":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T08:10:39Z","timestamp":1536135039000},"page":"1289-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Profile of the skin microbiota in a healthy Chinese population"],"prefix":"10.1111","volume":"45","author":[{"given":"Wanfang","family":"Zhai","sequence":"first","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology of First Affiliated Hospital Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Dermatology and Department of Dermatology of First Affiliated 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