{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:27:40Z","timestamp":1740144460087,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T00:00:00Z","timestamp":1536364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2015R1C1A2A01055073","2016M3D1A1021387"],"award-info":[{"award-number":["2015R1C1A2A01055073","2016M3D1A1021387"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>) is an <jats:italic>in situ<\/jats:italic> squamous cell carcinoma which is mostly found on sun\u2010damaged skin, and it is prevalent among Caucasians. However, there is a lack of research on evaluating the treatment efficacy of ingenol mebutate (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) on <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> in Asians. This study was intended to analyze the treatment outcomes of <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> in Korean patients with regards to clinical, dermoscopic and histopathological aspects. A prospective study on 46 Korean patients who were diagnosed with <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> and treated with <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> was conducted. Clinically, 80% (24\/30) of the patients showed an improvement at 8 weeks. Twenty out of the 30 (66.7%) patients were found to have achieved histopathological clearance. All local skin responses had disappeared at T4 in all patients. Patients with Fitzpatrick skin type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> were proven to exhibit better treatment outcomes, both clinically (<jats:italic>P<\/jats:italic> = 0.001) and histopathologically (<jats:italic>P<\/jats:italic> = 0.001), than those with Fitzpatrick skin type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>. The clinical and histopathological clearance rate of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> in Korean patients was 80% and 66.7%, respectively. The patients with Fitzpatrick skin type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> showed a tendency to have residual <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>, histopathologically after treatment with <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>. In conclusion, <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> could be an effective and safe treatment option on <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> in Korean patients. In addition, it would be helpful to carry out a cautious check\u2010up when treating <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> in patients with a darker skin color.<\/jats:p>","DOI":"10.1111\/1346-8138.14632","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T14:11:26Z","timestamp":1536415886000},"page":"1324-1330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of ingenol mebutate on actinic keratosis in a Korean population: A prospective clinical, dermoscopic and histopathological study from a single center"],"prefix":"10.1111","volume":"45","author":[{"given":"Jong Sic","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-9534","authenticated-orcid":false,"given":"Yu Ri","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miri","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0138-9885","authenticated-orcid":false,"given":"Hyun Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yeouido St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00710.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10227-001-0041-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103344"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04185.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103343"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1860"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1111170"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.11.8123"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.418"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/11470090-000000000-00000"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.036"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2015.04.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.2766"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14968"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13831"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07426.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.86"},{"issue":"3","key":"e_1_2_7_19_1","first-page":"285","article-title":"Efficacy and safety of imiquimod 3.75% from Lmax in actinic keratosis according to fitzpatrick skin type","volume":"15","author":"Alomar A","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14344"},{"issue":"9","key":"e_1_2_7_21_1","first-page":"29","article-title":"How to treat actinic keratosis? 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